乌腺金丝桃对抑郁症大鼠海马单胺类神经递质含量5-HT及5-HIAA的影响  

The Effect of Hypericum Attenuatum Choisy on the Contents of 5-HT and 5-HIAA from Hippocampus Monoamine Neurotransmitters of Depressive Rats

作　　者：李冀[1] 吴全娥[1] 高彦宇[1] 石鑫[1] 唐明哲[1] 曹明明[1] 

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040

出　　处：《中医药信息》2012年第5期18-20,共3页Information on Traditional Chinese Medicine

基　　金：国家十一五重大新药创制科技专项(2009ZX09103-302)

摘　　要：目的:探讨乌腺金丝桃对抑郁症大鼠海马单胺类神经递质五羟色胺(5-HT)及五羟吲哚乙酸(5-HIAA)含量的影响。方法:建立大鼠孤养结合慢性不可预计性应激抑郁模型,用酶联免疫法测定药物对单胺类神经递质5-HT及5-HIAA含量的影响。结果:乌腺金丝桃高剂量组(2.88g/kg)能显著提高大鼠慢性不可预计性应激抑郁模型的单胺类神经递质5-HT及5-HIAA的含量。结论:乌腺金丝桃具有一定的抗抑郁作用,其抗抑郁作用可能与增加海马单胺类神经递质5-HT及5-HIAA含量有关。Objective ： To study the effect of hypericum attenuatum Choisy. by surveying cerebral contents （5 - HT and 5 - HIAA） which exist in depressive model. Method ： Establish chronic stress rats model of depression by singly housing and exposing to unpredictable stressors, and detect cerebral contents of monoamine neuro- transmitters （5 - HT and 5 - HIAA） with ELISA. Result ： The high group of Hypericum attenuatum Choisy. （2. 88g/kg） could increase cerebral contents of 5 -HT and 5 -HIAA significantly. Conclusion ：Hypericum at- tenuatum Choisy. plays a role of the antidepression, and the possible mechanism of hypericum attenuatum Choisy. for antidepressant effect may be involved in increasing contents of 5 - HT and 5 - HIAA.

关 键 词：乌腺金丝桃 抗抑郁 慢性不可预计性应激抑郁模型 单胺类神经递质 

分 类 号：R285.5[医药卫生—中药学]