2型糖尿病患者胰岛素抵抗与体表测量指数的相关性分析  

Correlation analysis of insulin resistance and surface measurement index in type 2 diabetes patients

作　　者：萧丽军[1] 缪珩[1] 吴小梅[1] 何爱琴[1] 李万庆[2] 

机构地区：[1]南京医科大学第二附属医院内分泌科,江苏南京210003 [2]东南大学公共卫生学院,江苏南京210009

出　　处：《现代医学》2012年第5期541-545,共5页Modern Medical Journal

摘　　要：目的:探讨2型糖尿病胰岛素抵抗(IR)与体表测量指数的相关性。方法:选取2型糖尿病患者92例和健康对照31例。检测血压、空腹血糖(FPG)、空腹胰岛素(FINS)、血脂、糖化血红蛋白(HbA1c)、身高(H)、体重(W)、体重指数(BMI)、腰围(WC)、腹围、臀围、颈围、左上臂围(AC)、左大腿围、胰岛素抵抗指数(IRI),探讨各项指标间的相关性。结果:糖尿病组IRI显著高于对照组(P<0.05),而胰岛素敏感指数(ISI)、B细胞功能指数(HBCi)显著低于对照组(P<0.05)。糖尿病组IRI与BMI、WC呈正相关,相关系数分别为0.70、0.41。糖尿病组内总胆固醇随BMI的增加而增加,且差异有统计学意义(P<0.05),IAI随BMI的增加而降低。结论:2型糖尿病患者存在糖、脂代谢紊乱及IR,体表测量指标中BMI、WC与IRI显著正相关,控制BMI、WC可以有效改善IR。Objective： To observe and analysis the correlation of the insulin resistance and body surface measurement index in type 2 diabetes patients.Methods： 92 patients with diabetes and 31 healthy controls were enrolled.Blood pressure,fasting plasma glucose（FPG）,fasting insulin（FINS）,lipids,HbA1c,height（H）,weight（W）,body mass index（BMI）,waist circumference（WC）,hip circumference,neck circumference,the left upper arm circumference（AC）,the left thigh circumference,insulin resistance index（IRI） were studied to explore the correlation between the indicators.Results： The diabetic group IRI were significantly higher（P0.05）,and insulinsensitivity index（ISI）,β-cell function index（HBCi） was significantly lower than the control group（P0.05）.Diabetic group IRI and BMI,WC were positively correlated.Coefficient was 0.70,0.41.Diabetic group total cholesterol increased along with the increase of BMI with a significant difference（P0.05）,ISI decreased with the increasing BMI.Conclusion： Type 2 diabetes patients with glucose and lipid metabolism disorders,insulin resistance,body surface measure of BMI,WC was significantly positively correlated with IRI.Controlling BMI and WC can improve insulin resistance.

关 键 词：2型糖尿病 胰岛素抵抗 体表测量指数 相关性分析 

分 类 号：R587.1[医药卫生—内分泌]