重组人生长激素治疗生长激素缺乏症的疗效观察  

The Therapeutic Effect of Recombinant Growth Hormone in Children of Growth Hormone Deficient

作　　者：路宇[1] 于立君[1] 李国庆[1] 冯建华[1] 范惠子[1] 

机构地区：[1]哈尔滨医科大学附属二院儿内科,黑龙江哈尔滨150086

出　　处：《现代生物医学进展》2012年第28期5494-5496,共3页Progress in Modern Biomedicine

摘　　要：目的:正确评价重组人生长激素(rhGH)治疗儿童生长激素缺乏症(GHD)的疗效。方法:GHD患儿47例,给予rhGH0.1U/(kg.d),疗程3个月,并对其疗效进行观察。结果:身高(height)由(122±17.67)cm增至(125.32±17.50)cm,生长速率(growth rate)由<4cm/年增加到(10.40±3.74)cm/年。血清碱性磷酸酶(AKP)由(207±48.11)IU/L增至(261±45.29)IU/L。Ⅰ型前胶原羧基端伸展肽(PICP)由(97.80±14.94)ng/ml增至(119.50±24.10)ng/ml值。肌酐(Cr)由(40.20±8.28)umol/L变为(36.50±8.33)umol/L值。结论:rhGH是治疗GHD有效的药物。Objective： To investigate the therapeutic effect of recombinant growth Recombinant growth hormone（rhGH）in growth Hormone deficient （GHD）children before adolescence. Methods： This study included 47 children （30 boys and 17 girls）with GHD, who were treated With subcutaneous injections of rhGH 0.1 U/ （kg. d） before sleep for 3 months. Results： The mean height form （ 122± 17.67 ） cm to（ 125.32± 17.50）cm, Growth rate by 〈4cm/year increased to （10.40± 3.74） / cm year, The mean AKP form（207± 48.11） 1U/L to （261± 45.29） 1U/L, The mean he PICP form （97.80± 14.94）ng/m to（119.50± 24.10） ng/ml, The mean Cr form（40.20± 8.28）umol/L to （36.50± 8.33）. Conclusions： Recombinant growth Ilormone（rhGil） is an effective ＆rug for promoting height growth in GIlD children.

关 键 词：生长激素缺乏症 重组生长激素 儿童 

分 类 号：R723[医药卫生—儿科]