复方嗜酸乳杆菌联合利福昔明治疗急性细菌性腹泻疗效观察  

Curative effect of Lactobacillus acidophilus complex combined rifaximin in treatment of acute bacterial diarrhea

作　　者：田景波[1] 张长青[2] 曲燕[1] 李京军[1] 刘建军[1] 

机构地区：[1]青岛大学医学院第二附属医院,山东青岛266042 [2]青岛市第三人民医院,山东青岛266041

出　　处：《中国微生态学杂志》2012年第10期911-912,共2页Chinese Journal of Microecology

摘　　要：目的观察复方嗜酸乳杆菌联合利福昔明治疗急性细菌性腹泻的临床疗效。方法将100例急性细菌性腹泻患者随机分为A、B两组,A组50例给予复方嗜酸乳杆菌联合利福昔明治疗,B组50例单用利福昔明治疗,观察两组的总有效率、平均止泻时间、不良反应发生率。结果 A、B两组的总有效率分别为100%和92%,两组疗效比较,A组疗效优于B组,差异有统计学意义(P<0.05)。A组平均止泻时间为(37.9±10.0)h,短于B组(43.4±13.6)h(P<0.05)。治疗中A组和B组出现不良反应,但差异无统计学意义(P>0.05)。结论复方嗜酸乳杆菌联合利福昔明治疗急性细菌性腹泻的效果要优于单用利福昔明,并可缩短腹泻时间。Objective To observe the curative effect of Lactobacillus acidophilus complex combined rifaximin in treating acute bacterial diarrhea.Methods 100 cases of acute bacterial diarrhea patients were randomly divided into Group A and B.Group A（50 patients） was treated with the combination of Lactobacillus acidophilus complex and rifaximin,while Group B（50 patients） was treated with rifaximin only.The total effective rate,average time to diarrhea stops and the rate of side effects of both groups were observed.Results The total effective rate of Group A and Group B were 100% and 92% respectively.The difference was significant（P〈0.05）.The average time to diarrhea stops in Group A was（37.9±10.0） hours,shorter than the（43.4±13.6） hours in Group B（P〈0.05）.Side effects were found in group A and B,but there was no significant difference between them（P〈0.05）.Conclusion Combination of Lactobacillus acidophilus complex and rifaximin is better than rifaximin alone for treatment of acute bacterial diarrhea,and can help shorten the average time of antidiarrhea.

关 键 词：急性细菌性腹泻 复方嗜酸乳杆菌 利福昔明 疗效观察 

分 类 号：R378[医药卫生—病原生物学]