氯雷他定和热敷对发形霞水母刺胞毒素致兔皮肤炎症的拮抗作用  

Antagonism of loratadine and hot compress on dermatitis induced by nematocyst venom of Cyanea capillata in rabbits

作　　者：张智[1,2] 栾湘云[3] 王倩倩[1] 聂菲[1] 张黎明[1] 

机构地区：[1]第二军医大学海医系防化医学教研室,上海200433 [2]海军总医院急诊科 [3]第二军医大学附属长海医院妇产科

出　　处：《环境与健康杂志》2012年第10期899-901,F0003,共4页Journal of Environment and Health

基　　金：上海市卫生局青年基金(2007Y18)

摘　　要：目的利用水母蜇伤家兔模型,对比研究氯雷他定以及热敷两种方法缓解发形霞水母刺胞毒素导致的皮肤炎症的作用。方法对12只新西兰大耳白兔背部皮肤皮内注射水母刺胞毒素造成蜇伤模型,分为氯雷他定(0.55mg/kg,灌胃)、热敷(53℃,30 min)、氯雷他定(0.55 mg/kg,灌胃)+热敷(53℃,30 min)以及空白对照4组。在第1、2、3和14天观察皮肤炎症情况,并测量皮肤炎症灶直径。结果处理的前3天,各处理组皮肤炎症灶直径均小于对照组,3个处理组之间差异无统计学意义(P>0.05)。第14天时,与空白对照及其他两个处理组比较,氯雷他定组的皮肤炎症灶直径以及皮肤病理损伤程度均最小。结论氯雷他定可拮抗发形霞水母刺胞毒素对家兔皮肤的损伤,且不需同时热敷。Objective Using jellyfish-sting rabbit model to compare the abilities of hot compress and loratadine to ease skin inflammation caused by the nematocyst venom of Cyanea capillata. Methods Twelve New Zealand rabbits with intradennal injection of nematoeyst venom in back skin were divided into four groups. Except for blank eontrol group,the rest three groups were given different treatment for seven days： loratadine （0.55 mg/kg body weight, oral administration）, fomentation （53 ℃, 30 min）, fomentation joint with loratadine. Inflammation and pathological changes of skin were observed and measured at the 1st day, 2nd day, 3rd day and 14th day after injection of nematoeyst venom. Results In the first three days, no significant differences were seen between the three treatment groups. But at the 14th day, compared with the blank control group and the other two treatment groups, rabbits in loratadine group had the minimum diameter of skin inflammation and the least skin damage. Conclusion Oral administration of loratadine has a good therapeutic effect against the toxicity of the nematoeyst venom of Cyanea capillata to skin, and fomentation should not be used simultaneously

关 键 词：水母 刺胞毒素 氯雷他定 热敷 

分 类 号：R994.6[医药卫生—毒理学]