婴幼儿支原体肺炎血清TNF-α和IgE的变化及临床意义  

The changes and significance of serum TNF-α and IgE levels in infants with mycoplasma pneumoniae pneumonia

作　　者：王晓花[1] 张莉[1] 于莹[1] 

机构地区：[1]南京医科大学附属南京医院南京市第一医院儿科,江苏省210006

出　　处：《江苏医药》2012年第20期2402-2404,共3页Jiangsu Medical Journal

摘　　要：目的探讨婴幼儿支原体肺炎血清TNF-α和IgE的变化及其临床意义。方法应用酶联免疫吸附法和放射免疫法分别检测60例婴幼儿支原体肺炎患者(其中的34例伴有喘息发作)及35例同期健康体检婴幼儿血清TNF-α和IgE的浓度。结果婴幼儿支原体肺炎患者血清TNF-α和IgE的水平高于健康体检者(P<0.01),且支原体肺炎伴喘息患儿血清TNF-α和IgE的水平高于不伴喘息者(P<0.05)。结论 TNF-α和IgE在婴幼儿支原体肺炎的发生发展过程中起重要作用,也是支原体感染诱发婴幼儿喘息发作的重要因素之一。Objective To explore the changes and clinical significance of serum TNF-α and IgE in the infants with mycoplasma pneumoniae pneumonia（MPP）. Methods Serum levels of TNF-α and IgE were measured using ELISA and radioimmunoassay, respectively, in 60 infants with MPP（group A）, of whom 34 infants had wheezing, and 35 healthy infants（group B）. Results The serum levels of TNF-α and IgE in group A were significantly higher than those in group B（P〈0. 01）, which in group A were higher in the infants with wheezing than those without（P〈0. 05）. Conclusion The increase in serum levels of TNF-α and IgE may play important roles in the pathogenesis of MPP and wheezing attack in infants.

关 键 词：肺炎支原体 婴幼儿 肿瘤坏死因子α 免疫球蛋白E 

分 类 号：R725[医药卫生—儿科]