血浆BNP及CRP水平在充血性心衰与肺心病患者的动态变化  

Dynamic changes of plasma levels of BNP and CRP in patients with congestive heart failure and patients with pulmonary heart disease

作　　者：韦彩雯[1] 李宏松[1] 章敬玉[2] 姚能才[1] 窦存芳[1] 石来新[1] 卢英民[1] 

机构地区：[1]上海交通大学医学院附属新华医院心内科,上海202150 [2]上海交通大学医学院附属新华医院呼吸内科,上海202150

出　　处：《心血管康复医学杂志》2012年第5期501-503,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:探讨血浆脑钠肽(BNP)及C反应蛋白(CRP)水平在充血性心力衰竭(CHF)及肺源性心脏病(PHD)患者急性呼吸困难发作时及缓解后1周的变化并分析其临床意义。方法:入选CHF患者55例(CHF组),PHD患者47例(PHD组),分别测定各组患者急性呼吸困难发作时及缓解后1周血浆BNP及CRP水平。结果:与呼吸困难发作时比较,病情缓解后1周CHF患者血浆BNP[(1885±745)ng/L比(207±124)ng/L]、CRP[(36±11)mg/L比(8±6)mg/L]水平均明显下降,P均<0.05;PHD患者血浆BNP[(584±178)ng/L比(162±59)ng/L]、CRP水平亦均明显下降[(68±24)mg/L比(15±7)mg/L],P<0.05;呼吸困难发作时CHF组患者血浆BNP水平明显高于PHD组(P<0.05),CRP水平明显低于PHD组(P<0.05),呼吸困难缓解后1周两组间无显著差异。结论:脑钠肽及C反应蛋白水平与充血性心力衰竭及肺源性心脏病患者病情严重程度相关,在发作急性呼吸困难时检测二者水平有助于鉴别充血性心力衰竭或肺源性心脏病。Objective： To investigate changes of plasma levels of brain natriuretic peptide （BNP） and C reactive pro-tein （CRP） in patients with congestive heart failure （CHF） and panents With pulmonary set of acute dyspnea and a week after remission and analyze their clinical significance. Methods： A total of 55 CHF patients （CHF group） and 47 PHD patients （PHD group） were selected. The plasma levels of BNP and CRP were measured respectively in both groups at onset of acute dyspnea and one week after remission. Results： Compared with onset of dyspnea, there were significant decrease in plasma levels of BNP [ （1885± 745） ng/L vs. （207±124） ng/L] and CRP [ （36± 11） mg/L vs. （8± 6） mg/L] in CHF group at one week after remission, P〈0.05 both; there were also significant decrease in plasma levels of BNP [ （584±178） ng/L vs. （162±59） ng/L] and CRP [ （68 ＋ 24） mg/L vs. （15± 7） mg/L] in PHD group at one week after remission, P〈0.05 both; At onset of dyspnea, plasma BNP level in CHF group was significantly higher than that of PHD group （P〈0.05） and plasma CRP level in CHF group was significantly lower than that of PHD group （P〈0.05）. There were no significant differences in a- bove indexes between two groups at one week after remission. Conclusion： Levels of brain natriuretic peptide and C reactive protein are related with severity of congestive heart failure and pulmonary heart disease. Measurements of their levels at onset of acute dyspnea can help to identify congestive heart failure or pulmonary heart disease.

关 键 词：心力衰竭 充血性 肺心病 利钠肽 脑 C反应蛋白质 

分 类 号：R473.5[医药卫生—护理学]