多房棘球蚴感染与宿主相互作用的免疫学机制研究进展  

Research Advances in Interplay of Host Immune Mechanism and Echinococcus multilocularis Metacestodes

作　　者：娄忠子[1] 李宏民[1] 闫鸿斌[1] 倪兴维[1] 贾万忠[1] 

机构地区：[1]中国农业科学院兰州兽医研究所,家畜疫病病原生物学国家重点实验室,甘肃省动物寄生虫病重点实验室,农业部草食动物疫病重点开放实验室,农业部兽医公共卫生重点开放实验室,兰州730046

出　　处：《中国寄生虫学与寄生虫病杂志》2012年第5期401-405,共5页Chinese Journal of Parasitology and Parasitic Diseases

基　　金：公益性行业(农业)科研专项(No.200903036-07)~~

摘　　要：通过感染过程中宿主的固有免疫和获得性免疫的作用,多房棘球蚴可调节一系列虫体与宿主的相互作用效应,这些效应有助于虫体在宿主肝脏内的增殖和成熟,从而完成其生活史;对中间宿主来说,则可限制寄生所导致的病理变化的发展。本文主要针对多房棘球蚴免疫相关分子在提高寄生虫生存能力等方面与宿主间的免疫应答研究进行综述。Through affecting on host innate and acquired immune responses, Echinococcus multilocularis orchestrates various interplays that are beneficial not only to facilitate its intrahepatic proliferation and maturation during life cycle, but also to limit pathological process in its intermediate host. This review reveals the role of the metacestode＇s immune-related molecules in modulating host responses and optimizing its own survival.

关 键 词：多房棘球蚴 免疫相关分子 宿主-虫体相互作用 

分 类 号：R383.33[医药卫生—医学寄生虫学]