紫杉醇普朗尼克稳定化胶束的制备  

Study on the preparation of paclitaxel-loaded Pluronic stabilized micellae

作　　者：陈萍[1] 李娜[2] 胥洪娟[2] 李凌冰[2] 

机构地区：[1]山东大学附属省立医院,山东济南250021 [2]山东大学药学院,山东济南250012

出　　处：《中国医院药学杂志》2012年第20期1606-1610,共5页Chinese Journal of Hospital Pharmacy

基　　金：山东省科技攻关项目(编号:2008GG10002028)

摘　　要：目的:制备载紫杉醇的普朗尼克(Pluronic)稳定化胶束。方法:采用插入交联的方法,以普朗尼克P123为材料插入交联剂聚氰基丙烯酸正丁酯制备紫杉醇稳定化胶束。并对其理化性质如粒径,载药量,体外释放度等进行了测定。同时测定了该胶束对HepG-2肝癌细胞的细胞毒性。结果:所制备的载药胶束,多倍冲稀后仍能稳定存在。细胞毒性实验结果表明,稳定胶束对HepG-2肝癌细胞的细胞毒性显著高于原料药。结论:所制备的载紫杉醇胶束性质稳定,细胞毒性增加。OBJECTIVE Paclitaxel-loaded Pluronic stabilized mieelles were prepared. METHODS Paclitaxel loaded Pluronic stabilized micellae were prepared using Pluronic P123 with penetrating network of poly （butylcyanoacrylate） （PBCA）. The characteristics of micellae were measured such as particle size, drug loading and in vitro drug release from micellae. Cytotoxici ty tests against HepG-2 cells in vitro were also determined. RESULTS The stabilized miceliae were still stable after dilution many times. The cytotoxicity of paclitaxel-loaded micelles was remarkably higher than that of free drug. CONCLUSION Pacli taxel-loaded stabilized micellae were stable towards dilution and had high cytotoxicity than that of free drug.

关 键 词：胶束 稳定性 普朗尼克 聚氰基丙烯酸正丁酯 

分 类 号：R943[医药卫生—药剂学]