铁螯合剂和铜螯合剂抗肿瘤活性研究进展  

Anti-tumour activity of iron chelators and copper chelators:research advances

作　　者：林莉[1,2] 钟武[1] 董陆陆[2] 

机构地区：[1]军事医学科学院毒物药物研究所,北京100850 [2]哈尔滨医科大学药学院,哈尔滨150081

出　　处：《国际药学研究杂志》2012年第5期368-372,378,共6页Journal of International Pharmaceutical Research

基　　金：国家重大新药创制科技重大专项-创新药物研究开发技术平台(2009ZX09301-002)

摘　　要：铁和铜均是人体的必需微量元素。肿瘤细胞内铁和铜的含量均高于正常细胞,去除肿瘤细胞内过多的铁和铜可以抑制肿瘤细胞增殖、DNA合成和血管形成,产生活性氧簇,从而诱导细胞损伤。因此,铁螯合剂和铜螯合剂作为重要的抗癌药物受到日益广泛的关注。本文主要综述近年来铁螯合剂和铜螯合剂的抗肿瘤活性研究进展。Iron and copper arc the essential trace elements in human body. The contents of iron and copper in neoplastic cells are much higher than those in the normal ones. The deprivation of excess iron and copper in tumor cells can inhibit the proliferation of tumor cells, DNA synthesis, the formation of vessels and generate active oxygen species, which may induce cellular injury. Therefore, iron chelators and copper chelators as important anti-tumor agents are increasingly attracting our attention. In this parper, the recent advances of iron chelators and copper chelators are reviewed.

关 键 词：铁螯合剂 铜螯合剂 抗肿瘤药 

分 类 号：R96[医药卫生—药理学]