转化生长因子β对血管重塑的调节作用  

Regulatory effect of transforming growth factor β on vascular remodeling

作　　者：宋灿[1,2] 黄亚男[2] 霍海如[2] 谭余庆[2] 

机构地区：[1]安徽中医学院药理学教研室,合肥230031 [2]中国中医科学院中药研究所中药安全评价中心,北京100029

出　　处：《国际药学研究杂志》2012年第5期405-408,共4页Journal of International Pharmaceutical Research

摘　　要：转化生长因子β(TGF-β)是一种能够调节细胞生长、分化及细胞外基质生成的生长因子。血管重塑是很多心血管疾病发生的共同病理过程,TGF-β能够诱导血管外膜成纤维细胞增生及其向肌成纤维细胞的表型转化,在血管损伤部位促进血管重塑等一系列改变。Smad蛋白参与TGF-β细胞内信号转导,通过与不同蛋白相结合形成复合体,调控TGF-β靶基因的表达,从而发挥多种生物学功能。本文就TGF-β对血管外膜成纤维细胞增殖、迁移和表型转化的影响进行综述。Transforming growth factor β （TGF-β） is a growth factor regulating cell proliferation, differentiation and the produc- tion of extracellular matrix. Vascular remodeling is a common pathological process of many cardiovascular diseases. TGF-β can acceler- ate vascular adventitial fibroblasts proliferation, induce the transdifferentiation of vascular adventitial fibroblasts into myofibroblasts, and promote the vascular remodeling and a series of changes in vascular injury sites. Smad proteins involved in TGF-β intracellular sig- nal transduction can regulate the expression of TGF-β target gene by binding with differenot proteins, so as to perform multiple biologi- cal functions. This review introduces the influence of TGF-β on the proliferation, migration and phenotype transformation of vascular adventitial fibroblasts.

关 键 词：转化生长因子β血管外膜成纤维细胞 增殖 迁移 表型转化 

分 类 号：R96[医药卫生—药理学]