电针对实验性2型糖尿病大鼠胰岛素抵抗和瘦素的影响  

Effect of Electro-acupuncture on Insulin Resistance and Leptin in the Experimental Rats with Type 2 Diabetes Mellitus

作　　者：黄振[1] 阮继源[2] 

机构地区：[1]杭州市第一人民医院,浙江杭州310006 [2]浙江中医药大学第三临床医学院,浙江杭州310000

出　　处：《中华中医药学刊》2012年第10期2332-2335,共4页Chinese Archives of Traditional Chinese Medicine

摘　　要：目的:探讨电针对2型糖尿病(T2DM)胰岛素抵抗和瘦素作用的机制。方法:采用小剂量STZ尾静脉注射结合高热量饲料喂养的方法复制T2DM大鼠模型,将成模大鼠随机分为模型对照组(简称对照组)和电针治疗组(简称电针组),另设正常对照组(简称正常组),每组8只。观察电针"胰俞"穴和"后三里"穴对大鼠体重、空腹血糖(FBG)、总胆固醇(TC)、甘油三酯(TG)、空腹血清胰岛素(FINS)、空腹血清瘦素(LEP)和胰岛素敏感指数(ISI)的影响。结果:电针治疗前,电针组和对照组体重、FBG、FINS、TC、TC和LEP均明显高于正常组,而ISI则降低(均P<0.05),有显著性差异。电针治疗后,电针组体重、FBG、FINS、TC、TC和LEP与本组治疗前和对照组相比均明显下降,而ISI则上升(均P<0.05),有统计学意义。结论:(1)电针能减轻体重,改善脂质代谢紊乱,具有良好的减肥降脂作用。(2)电针能降低血糖及胰岛素水平,改善胰岛素抵抗。(3)电针能降低血清瘦素水平,改善瘦素抵抗。(4)电针改善胰岛素抵抗的机制可能与降低血清瘦素水平,改善瘦素抵抗有关。Objective ：To discuss the mechanism of electro acupuncture（EA） therapy on insulin resistance and leptin in the experimental rats with type 2 diabetes mellitus （T2DM）. Method：We reproduced rats model of T2 D M by combining injection of small dosage of STZ from the tail vein with feeding of high fat diet. The T2DM rats made into model suc cessfully were randomly divided into the model control group rats （ brief name for control group） and the EA treatment group rats（ brief name for EA group） ,and normal control group（ brief name for normal group） ,with 8 in every group. Ob serve effect of EA on body weight, FBG, TC,TG, FINS, LEP and ISI of the T2DM rats of Yishuand Housanli acupoint. Re sults：Before EA treatment, comparing with the normal group, the body weight, FBG, TC, TG, FINS and LEP in the EA group and control group increased significantly, but the ISI decreased significantly（ P 〈 0.05 ）. The difference was signifi cant. After EA treatment, comparing with the control group, the body weight, FBG,TC, TG, FINS and LEP in the EA group decreased significantly, but the ISI increased significantly（ P 〈 0.05）. The difference had statistical significance. Conclusions ： （ 1 ） EA can lose BW and improve lipid metabolism disorder, so it can lose weight and reduce BL significant ly. （2）EA can lower FBG and FINS levels and improve IR in rats with T2DM. （3）EA can lower LEP level and improve LR. （4） The mechanism of IR improvement with EA treatment probably has correlation with decrease of LEP and LR im provement.

关 键 词：电针 2型糖尿病 胰岛素抵抗 瘦素 瘦素抵抗 

分 类 号：R322[医药卫生—人体解剖和组织胚胎学]