异嗜性小鼠白血病病毒相关病毒(XMRV)与人类疾病的相关性研究进展  

Research Progress of the Associativity in Xenotropic Murine Leukemia Virus-Related Virus(XMRV) and Human Diseases

作　　者：魏志涛[1] 杨勇[1] 

机构地区：[1]解放军总医院泌尿外科,北京100853

出　　处：《现代生物医学进展》2012年第25期4998-5000,共3页Progress in Modern Biomedicine

基　　金：军队"十一五"面上项目基金(06MA297);北京市科技攻关项目基金(Z090507017709031);解放军总医院科技创新苗圃科研基金(XMRV感染与中国人前列腺癌发病的相关性研究);社会合作基金(内分泌辅助下放射性离子植入术治疗进展期前列腺癌的临床研究)

摘　　要：异嗜性小鼠白血病病毒相关病毒(XMRV)是第一个能够感染人的γ型逆转录病毒。由于逆转录病毒具有插入宿主染色体引发基因突变的特性,以及部分γ型逆转录病毒携带原癌基因并能诱发癌症,致使XMRV感染与人类癌症发病之间的关系受到广泛关注。西方研究表明XMRV感染与前列腺癌和慢性疲劳综合症的发病有一定的相关性,因此成为研究热点。但各地报告的检测结果却不尽相同,甚至有矛盾之处。XMRV致瘤性可能是能够激活内源性原癌基因,从而导致细胞转化。在我国,目前尚未见XMRV感染与人类疾病关系的相关研究报道。XMRV感染的地区间或人群间差异性也有待研究。其感染的途径及临床可普及应用的检测手段也未被阐明,在我国不同地区不同类型人群中的感染率、与疾病的关系、对我国人口健康的潜在影响,均有待研究。Xenotropic murine leukemia virus-related virus（XMRV） was a γ-retrovirus which is able to infect humans.Retro-virus can insert into the host chromosome and cause gene mutation,and some of the γ-retroviruses carrying the proto-oncogene can in-duce cancer.In this way,the relationship between XMRV infection and human cancer＇s incidence had been widespread concerned.Western scholars had shown that XMRV is considered a relationship with the incidence of prostate cancer and chronic fatigue syndrome in the Westerners,and become a research hotspot.The results of testing were different in Europe and U.S,even contradictions.The XM-RV tumorigenicity may be able to activate the endogenous proto-oncogenes,leading to cell transformation.In China,there is no research report in the relationship of XMRV infection and diseases.The difference of XMRV infection in regions and groups should be re-searched.The ways of infection and clinical detection means had not been clarified,the infection rates in different groups of people,in different regions of China and in different diseases,the potential impact on the health of Chinese people are all to be researched.

关 键 词：异嗜性小鼠白血病病毒相关病毒(XMRV) 逆转录病毒 前列腺癌 慢性疲劳综合症 

分 类 号：Q95-3[生物学—动物学] R378[医药卫生—病原生物学]