妊娠期妇女血中α1-抗胰蛋白酶与纤维蛋白原相关性研究  

Correlation ofα1-Antitrypsin and Fibrinogen in Pregnancy

作　　者：裘俭[1] 黄雅萍[1] 张玲玲 吕红[1] 

机构地区：[1]浙江大学医学院附属妇产科医院,浙江杭州310006

出　　处：《中国实验诊断学》2000年第4期160-161,共2页Chinese Journal of Laboratory Diagnosis

摘　　要：目的　了解正常非孕妇女及早、中、晚各妊娠期妇女血中 αｌ－ＡＴ及ＦＩＢ的浓度，分析这２种因子的变化及相互关系。方法　采用免疫比浊法检测７４例非孕及早、中、晚妊娠妇女血浆中的 αｌ－ＡＴ及ＦＩＢ的浓度。结果 αｌ－ＡＴ随孕周增加而减少，ＦＩＢ随孕周增加而增加，ＦＩＢ与 α１－ＡＴ呈显著负相关，两者的回归方程为 ｙ＝－７９．１２ｘ＋６１９．１８（ｘ为 α１－ＡＴ，ｙ为ＦＩＢ）。结论ａｌ－ＡＴ参与妊娠期凝血抗凝系统的调节，αｌ－ＡＴ对妊娠期间高凝状态有重要作用。Objective To evaluate the normal concentrations of αl-AT and FIB in both non-pregnancies and pregnancies at early stage, middle stage and late stage and analyze the correlation between the two factors. Methods Immunoturbidimetric assay methods were used to detect αl-AT and FIB in 74 samples. Results α l-AT was decreased and FIB was increased with the pregnancy stage. FIB and α l-AT had significantly negative correlation. The linear equation was y=-79.12x+619.18 (x is α l-AT, y is FIB). Conclusion The α l-AT takes part in the regulation of the coagulation and fibrolysis system in pregnancies; α l-AT is an important factor in high coagulation condition in pregnancies.

关 键 词：Α1-抗胰蛋白酶 纤维蛋白原 妊娠 

分 类 号：R714.25[医药卫生—妇产科学] R446.112[医药卫生—临床医学]