血、尿Ⅳ型胶原测定对糖尿病肾病早期诊断的意义  

The significance or determination of Ⅳ type collagen in blood and urine in the early diagnosis of diabetic nephropathy

作　　者：夏成云[1] 邓隆银[1] 文晓冬[1] 刘晓惠[1] 

机构地区：[1]川北医学院附属医院内科,四川南充637000

出　　处：《中国实验诊断学》2000年第4期174-175,共2页Chinese Journal of Laboratory Diagnosis

摘　　要：目的　探讨血、尿Ⅳ型胶原在糖尿病肾病（ＤＮ）早期诊断中的价值。方法１０８例糖尿病患者按照Ｍｏｇｅｎｓｅｎ法分类分为无糖尿病肾病组（无ＤＮ组）、早期糖尿病肾病组（早期ＤＮ组）、临床糖尿病肾病组（临床ＤＮ组）３组。另选取３８例健康人为对照组。各组均采用放射免疫法测定血、尿Ⅳ型胶原含量，并行比较分析。结果无 ＤＮ组、早期 ＤＮ组、临床 ＤＮ组血、尿Ⅳ型胶原含量与对照组比较均有显著性差异（Ｐ＜０．０５Ｈ０．０１，Ｐ＜０．００５）。随着ＤＮ病情加重，血、尿Ⅳ型胶原含量逐渐升高。结论血、尿Ⅳ胶原可作为ＤＮ早期诊断的敏感指标。Objective To probe the value of Ⅳ type collagen (ⅣC) in blood and urine in the early diagnosis as diabet- icnephropathy. Methods 108 cases with DM were devided into 3 groups as None-DN, early DN and clinical DN groups ac- cording to Mognesen, meanwhile 38 healthy cases were selected as control group. The original IVC content was determined by radioimmunoassay and analysed comparatively in each group. Results The original IVC content in none-DN, early-DN and clinical DN groups has striking difference compared with the control group (P<0.05 or 0.005). The content of IVC in blood and urine were increased, when the condition of DN patients was getting worse. Conclusion IVC in blood and urine can be consideredas a sensitive index in the early diagnosis of DN.

关 键 词：Ⅳ型胶原 糖尿病肾病 早期诊断 血 尿 

分 类 号：R587.2[医药卫生—内分泌] R692.04[医药卫生—内科学]