参麦注射液改善兔休克再灌注期间肠道灌注及氧合  

Protective Effect of Shen-Mai Injectionon Perfusionand Oxygenation of Intestinal Mucosal during Hemorrhagic Shock-reperfusion in Rabbits

作　　者：夏中元[1] 郑利民[2] 黄海波[1] 

机构地区：[1]湖北医科大学附属第一医院麻醉科,武汉市430060 [2]深圳市中心医院麻醉科

出　　处：《临床麻醉学杂志》2000年第9期452-454,共3页Journal of Clinical Anesthesiology

摘　　要：目的 :研究参麦注射液 (SM)对休克再灌注期间肠道灌注及氧合的影响。方法 :2 1只兔随机分为对照组(Ⅰ组 ,n =6 ) ,休克再灌注组 (Ⅱ组 ,n =9)及SM治疗组 (Ⅲ组 ,n =6 )。采用Lamson休克再灌注模型 ,通过Tonometry张力计及门静脉置管 ,观察休克前、休克 1小时、再灌注 1和 2小时乙状结肠肠粘膜 pH(pHi)、门静脉血气及血流动力学变化。结果 :Ⅱ组再灌注期间pHi及门静脉血 pH(pHpV)持续低于Ⅰ组 (P <0 0 5 )及休克前 (P <0 0 1) ,且二者线性相关 ;而门静脉血氧饱和度 (SpVO2 )高于Ⅰ组 ,与 pHi呈负相关。Ⅲ组再灌注 1和 2小时 pHi及pHpV较Ⅱ组明显升高(P <0 0 5 ) ,而SpVO2 恢复至Ⅰ组水平。Ⅲ组再灌注期间MAP及CO高于Ⅱ组 ,而外周血管阻力 (SVR)低于Ⅱ组 (P<0 0 5 )。Ⅱ组除再灌注 1小时MAP外各指标与Ⅰ组无差异。结论Objective :ToinvestigatetheeffectsofShen Maiinjection(SM )onperfusionandoxygenationofintestinal tractduringreperfusioninshockedrabbits .Methods:Twenty onerabbitsweredividedintocontrolgroup (Ⅰ ,n =6 ) ,shock reperfusiongroup (Ⅱ ,n =9)andSM group (Ⅲ ,n =6 ) .IntestinalintramucosalpH (pHi)ofthesigmoidcolonandportalveinbloodgaswasobservedbeforeshock ,at 1houraftershock ,1hourand 2hoursofreperfusion .Results :pHiandportalvein pHingroupⅡweresignificantlylowerthanthoseingroupⅠ (P <0 0 1) ,butportalveinSO2 increasedobviouslyduring reperfusion .TherewasagoodlinearpositivecorrelationbetweenpHiandportalveinpH .PortalveinSO2 ingroupⅡwas greaterthanthatingroupⅠandhadanegativecorrelationwithpHi.pHiandportalveinpHofgroupⅢincreasedsignifi cantlycomparedwiththoseofgoupⅡ (P <0 0 5 ) ,whileSO2 ofgroupⅢreturnedtothelevelofgroupⅠ .MAPandCOof groupⅢwerehigherthanthoseofgroupⅡafter 1houror 2hoursreperfusion (P <0 0 5 ) .COofgroupⅢremainedatahighlevelduringreperfusion .ButSVRofgroupⅢwaslowerthanthatofgroupⅡduringreperfusion .Conclusion :SMim provesperfusionandoxygenationofintestinaltractduringreperfusion .

关 键 词：参麦注射液 休克 氧合 失血性休克 肠道灌注 

分 类 号：R614[医药卫生—麻醉学]