小剂量ASA预防高血压病人IS的10年研究  

A ten years clinical study of small dose Aspirin for preventing ischemic stroke on hypertensive patients

作　　者：马亚东[1] 邱小莹[1] 王莉[1] 李兰英[1] 陈莉[1] 吕建红[1] 周景春[1] 

机构地区：[1]内蒙古自治区医院干部保健所,内蒙古呼和浩特010017

出　　处：《内蒙古医学杂志》2000年第4期252-256,共5页Inner Mongolia Medical Journal

基　　金：内蒙古自治区卫生厅1998年科研课题!课题号 98 2 0

摘　　要：目的 :探讨中老年高血压病人长期服用小剂量阿斯匹林 (ASA)预防缺血性脑卒中 (IS)的临床价值 ;方法 :对 1 2 1 8例男性中老年高血压病及 2 80 2例无高血压的男性中老年者ASA连续干预前后 1 0年的IS发病、死亡等相关问题对照研究 ;结果 :ASA干预前 ,高血压IS发病率为 1 4 78‰ ,显著高于对照组 (2 86‰ ) ,ASA连续干预治疗的9年中 ,高血压组IS发病率呈现明显下降趋势 ,其发病危险度 (RR)较干预前减低 40 %左右。而ASA未使出血性脑卒中 (HS)发病率和死亡率增加 ;结论 :长期服用ASA对于中老年高血压IS发病有明显预防作用 ,且不增加HS的危险性。Objective:To inquire the clinical Value of small dose of Aspirin administered long terms on middle and old age hypertensive patients;Methods:Contrast study was done between 1218 male cases of middle and old age hypertensive patients and 2802 male cases with no hypertension the incidence rate of ischemic stroke and the follow mortality rate were compared before and after using ASA between these twogroup;Results:The incidence rate of ischemic stroke in hypertensive patients was 14.78‰。obviously higher the control group 2.86‰,After using Aspirin for nine years the rate clecreased clearly,and the relative risk reduced about 40%;while the incidence rate and mortality rate of ischemic stroke in patients without taking Aspirin is much higher;Conclusion:The result shows that longterm Aspirin administration can effectively prevent ischemic stroke in middle and old age hypertensive patients and dont increase the risk of hemorrhagic stroke. [

关 键 词：阿斯匹林 缺血性脑卒中 中老年 高血压 

分 类 号：R544.106[医药卫生—心血管疾病] R743.310.1[医药卫生—内科学]