手足口病患儿血清IL-6、IL-10、IL-17水平的变化及其临床意义  

The change and clinical significance of serum IL-6、IL-10 and IL-17 level in children with hand,foot and mouth disease

作　　者：黄小霏[1] 范联[1] 陈国华[1] 

机构地区：[1]广东省佛山市妇幼保健院儿科,528000

出　　处：《重庆医学》2012年第30期3157-3159,共3页Chongqing medicine

摘　　要：目的探讨手足口病(HFMD)患儿外周血白介素(IL)-6、IL-10、IL-17水平及其在HFMD发展过程中的变化。方法采用酶联免疫吸附实验(ELISA)双抗体夹心法测定56例HFMD患儿(急性期、恢复期)及同期40例健康对照组儿童血清IL-6、IL-10、IL-17的含量;并对HFMD患儿急性期、恢复期及健康对照组进行两两比较;HFMD患儿中重症患儿、普通患儿及健康对照组进行两两比较,了解IL-6、IL-10、IL-17在HFMD发展过程中的变化。结果 (1)HFMD患儿急性期IL-6、IL-10及IL-17水平显著高于健康对照组(P<0.01);恢复期IL-6及IL-17水平与对照组比较,差异无统计学意义(P>0.05)。而IL-10水平仍高于健康对照组(P<0.01)。(2)HFMD重症患儿急性期IL-6、IL-10及IL-17水平高于普通型患儿,差异有统计学意义(P<0.01);至恢复期,重症组仍未能恢复正常水平,与对照组比较差异有统计学意义(P<0.01)。(3)急性期IL-6与IL-10呈负相关关系(P<0.05);IL-6与IL-17呈正相关关系(P<0.01);IL-10与IL-17呈负相关关系(P<0.05)。恢复期,IL-6与IL-10呈负相关关系(P<0.05);IL-6与IL-17呈正相关关系(P<0.01);IL-10与IL-17无相关关系(P>0.05)。结论 HFMD患儿急性期炎性细胞因子(IL-6、IL-17)水平显著升高,而抑制性细胞因子IL-10水平升高持续到恢复期。Objective To study the changes and clinical significance of serum interleukin（IL）-6,IL-10,IL-17 levels in the children with hand foot and mouth disease（HFMD）.Methods The serum concentration of IL-6,IL-10,Il-17 in 56 cases of HFMD children（acute stage and recovery stage） and 40 cases of healthy controls were measured by ELISA.The cytokines levels were compared pairly.Results（1）Compared with healthy controls,The levels of IL-6,IL-10 and IL-17 in acute stage of HFMD were significantly increased in HFMD children（P〈0.01）.There was no significant difference of the levels of IL-6 and IL-17 between the convalescence of HFMD and healthy children（P〉0.05）,However the levels of IL-10 in recovery stage of HFMD were higher than healthy children（P〈0.01）.（2）In acute stage,the levels of IL-6,IL-10,Il-17 in severe children of HFMD were higher than those in general children（P〈0.01）,and also significantly difference from those in healthy controls in recovery stage（P〈0.01）.（3）Spearman correlation analysis revealed that IL-6 and IL-17 were negatively correlated with IL-10（P〈0.05）;IL-6 positively correlated with and IL-17 in acute stage（P〈0.01）.In recovery stage IL-6 was negatively correlated with IL-10（P〈0.05）,positively correlated with IL-17（P〈0.01）;IL-10 and IL-17 have no correlative relation（P〉0.05）.Conclusion The levels of IL-6 and IL-17 were significantly increased in acute stage of HFMD children.The persistent elevation of serum IL-10 level was found in HFMD patients after convalescence.

关 键 词：手足口病 白细胞介素类 儿童 

分 类 号：R725.1[医药卫生—儿科]