小剂量纳洛酮用于腹腔镜全麻术后催醒的临床研究  

The clinical study of small dose naloxone for laparoscopic surgery after general anesthesia wake-up

作　　者：杨吉军[1] 谢礼[1] 王德明[1] 桂培根[1] 张群峰[1] 

机构地区：[1]南华大学附属第二医院ICU,421001

出　　处：《中国现代药物应用》2012年第22期13-14,共2页Chinese Journal of Modern Drug Application

摘　　要：目的观察小剂量纳洛酮用于腹腔镜全麻术后催醒的有效性及安全性。方法 100例妇科腹腔镜手术患者随机分为A、B两组,全组诱导后均以芬太尼、七氟醚、异丙酚维持麻醉,术毕A组用0.4～0.8mg纳洛酮催醒,B组给予0.2～0.4mg纳洛酮催醒,观察并记录两组的苏醒拔管时间、平均压(MAP)、心率(HR)、呼吸频率(f)、潮气量(VT)的变化及患者的不良反应。结果两组患者拮抗后f、HR、VT均增加,A组HR显著加快,MAP显著升高,与B组相比,差异有统计学意义(P<0.05)。两组苏醒拔管时间无明显差异,拮抗后A组5例出现躁动、恶心呕吐,B组3例。结论小剂量纳洛酮用于全麻术后催醒,拮抗呼吸抑制及催醒效果好,值得推广使用。Objective To observe the small dose of naloxone＇ efficacy and safety of snooze function af- ter general anesthesia for laparoscopy. Methods 100 cases of gynecologic laparoscopic surgery were randomly divided into A, B groups. The whole patients used fentanyl, sevoflurane, propofol to maintain anesthesia after induction. After surgery, group A was injected 0. 4 ~ 0. 8 mg naloxone to Accelerate recovery, while group B was given 0. 2 ~ 0. 4 mg naloxone. The waken extubation time, MAP, HR, f, VT and adverse effects were ob- served and recorded. Results f and VT were increased in all groups after antagonizing, HR and MAP increased significantly in the group A compared with group B （P 〈 0. 05 ）. There was no significant difference in recovery time between two groups. After antagonized with naloxone, 5 patients had agitation, nausea and vomiting in group A, while 3 cases in group B. Conclusion The use of small dose naloxone for patients after general anes- thesia has a better effect in antagonizing respiratory depression and accelerating recovery, which should be wide- ly used.

关 键 词：全身麻醉 纳洛酮 腹腔镜 苏醒 

分 类 号：R614[医药卫生—麻醉学]