新型常山碱类抗球虫化合物的合成  

Synthesis of Novel Febrifugine Anticoccidial Compounds

作　　者：严春蓉[1] 吕春兰[1] 徐慎颖[1] 李慧[2] 

机构地区：[1]宜宾学院化学与化工学院,四川宜宾644000 [2]宜宾学院外国语学院,四川宜宾644000

出　　处：《宜宾学院学报》2012年第6期54-56,共3页Journal of Yibin University

基　　金：国家自然科学基金资助项目(21072135);宜宾学院博士科研启动项目(2010B09)

摘　　要：通过2-溴-N-(2-硝基苯)乙酰胺和取代的喹唑啉酮在NaH催化下发生亲核取代反应,再经过氢化、酸化合成了2个新型常山碱类抗球虫药物——N-(2-氨基苯基)-2-喹唑啉酮乙酰胺盐酸盐.其中2-溴-N-(2-硝基苯)乙酰胺通过溴乙酰氯与邻硝基苯胺反应制备,取代的喹唑啉酮使用取代的邻氨基苯甲酸与甲酰胺反应合成.化合物的合成具有合成路线短、产率高、原料易得等优点.目标化合物的结构均经1H NMR,IR和HRMS等方法确证.Tow novels N-（2-aminophenyl）-2-quinazolinone-acetamide hydrochloride were synthesized through nucleophilic substitution,hydrogenation and acidification.The nucleophilic substitution was reacted between 2-bromo-N-（2-nitrophenyl）acetamide and various substituted quinazolinone under the catalysis of NaH.Among them,2-bromo-N-（2-nitrophenyl）acetamide was synthesized by a reaction between acetyl chloride and o-nitroaniline.And the substituted quinazolinone was synthesized by using aminobenzoic acid and formamide.The new process is characterized by short synthetic route,high yield and cheap raw materials.The structures of these compounds were confirmed by 1H NMR,IR spectra and HRMS.

关 键 词：2-溴-N-(2-硝基苯)乙酰胺 取代的喹唑啉酮 常山碱类抗球虫药物 N-(2-氨基苯基)-2-喹唑啉酮乙酰胺盐酸盐 合成 

分 类 号：O629.3[理学—有机化学]