血清铁蛋白及IL-8动态检测在新生儿缺血缺氧性脑病患儿中的临床意义  

Study on the effect of serum ferritin and IL-8 in neonatal hypoxic ischemia encephalopathy

作　　者：陈艳萍 孙雪荣 魏涛[2] 高中波 

机构地区：[1]青岛市妇女儿童医院检验科,山东省266012 [2]青岛市市立医院,山东省266012 [3]青岛市平度中医院,山东省青岛市266000

出　　处：《中国优生与遗传杂志》2012年第10期85-86,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨血清铁蛋白及白细胞介素8动态监测在缺氧缺血性脑病患儿中的作用。方法分别检测45例HIE患儿及正常对照组30例新生健康儿出生后(48h内)及治疗5天和7天后的血清铁蛋白与白细胞白介素8水平。结果HIE组患儿出生SF水平为(356±108)ng/ml与对照组(332±112)ng/ml比较无明显差异(P>0.05),治疗5天及7天后的SF水平分别(568±223)ng/ml,(432±169)均高于对照组SF水平(268±96)ng/ml、(226±86)ng/ml(P<0.01),HIE患儿IL-8出生及治疗5天后及7天的水平分别为(156.2±33.2)pg/ml、(135.3±22.1)pg/ml、(120.1±19.2)pg/ml与对照组(98.2±12.1)pg/ml、(96.4±11.1)pg/ml、(95.6±13.2)pg/ml比较均有显著性差异(P<0.01)。结论 HIE患儿脑组织损伤后SF与IL-8水平明显升高,但IL-8的变化相对较早,因此动态检测二者含量有助于临床医生监测HIE患儿的病情,及时调整治疗方案。对患儿的早期治疗及预后有一定帮助。Objective： To study the effect of serum ferritin and IL-8 in neonatal hypoxic ischemia encephalopathy（HIE）.Methods： To measure the serum ferritin and IL-8 levels in 45 neonates of HIE within 48h after birth and 5 and 7 days after cured.At the same time measure the serum ferritin and IL-8 levels of 30 healthy neonates.Results： The serum ferritin level of HIE within 48h after birth were（356±108）ng/ml,and there were no significant statistical difference with healthy neonates（332±112）ng/ml（P〈0.05）,but the serum ferritin level of HIE neonates 5 and 7 day after cured HIE（568±223）ng/ml,（432±169）ng/ml both had significant statistical difference with healthy neonates（268±96）ng/ml、（226±86）ng/ml（P〈0.01）;the IL-8 levels of HIE within 48h after birth／ 5 and 7 days after cured HIE all had significant statistical differrence with healthy neonates（156.2±33.2）pg/ml、（135.3±22.1）pg/ml、（120.1±19.2）pg/ml compared with（98.2±12.1）pg/ml、（96.4±11.1）pg/ml、（95.6±13.2）pg/ml（P〈0.01） Conclusion： The serum ferritin and IL-8 levels in neonates of HIE increased after the injury of brain,but the change of IL-8 level are earlier than serum ferritin level.So measure the serum ferritin and IL-8 levels at the same time can help the clinical doctor detect the severity of neonates of HIE and regulate the treatment prescription.

关 键 词：血清铁蛋白 白细胞介素8 缺氧缺血 婴儿 再灌注损伤 

分 类 号：R722.1[医药卫生—儿科]