阿德福韦酯联合GSH治疗慢性重型乙型肝炎疗效观察  

Observation on the effect of adefovir dipivoxil combined with reduced glutathione on severe chronic hapaitits B patients.

作　　者：郑成芳[1] 

机构地区：[1]儋州市第一人民医院,海南儋州571700

出　　处：《中国热带医学》2012年第9期1107-1109,共3页China Tropical Medicine

摘　　要：目的探讨阿德福韦酯联合还原型谷胱甘肽治疗慢性重型乙型肝炎的临床疗效及安全性。方法将52例被确诊为慢性重型乙型肝炎的患者分为2组,其中对照组20例给予常规治疗;治疗组32例,在常规治疗的基础上加用还原型谷胱甘肽1.2g加入到5%葡萄糖注射液250ml静滴,每日一次。阿德福韦酯lO mg,每天一次口服。分别观察2组治疗前后肝功能和凝血酶原活动度(PrA)、血清HBV DNA水平变化及疗效情况。结果治疗组总有效率为83%,对照组为53.0%,差异有统计学意义(t=8.13,P<0.01)。治疗后与对照组相比,治疗组存活患者的总胆红素降低、PTA升高,血清HBVDNA水平降低具有统计学意义(P<0.01)。未发现明显的毒副作用。结论阿德福韦酯联合还原型谷胱甘肽治疗慢性重型乙型肝炎具有较好的疗效和安全性,值得临床推广。Objective To investigate the efficacy and safety of adefovir dipivoxil combined with reduced glutathione in treatment of chronic hapaitits B patients.Methods The 52 confirmed hepatitis B patients were randomly divided into control group consisted of 20 cases and treated with conventional therapy and treatment group consited of 32 cases and treated with conventional therapy and reduced glutathione added in 5% glucose 250ml by intravenous injection,one time a day,plus adefovir dipvoxil 110mg,orally taken one time a day for a course of 4 weeks.The indicators of liver function,the activity of prothrombin（PrA）,the level of HBV DNA and therapeutic effect were observed and analuysed.Results The total effective rates in the treatment group and control group were 83.0% and 53.0%,showing significantly statistical differences between the two groups（t=8.13,P0.01）.Compared to the control group,the total bilirubin level in the patients of treatment group decreased,but that of the prothrombin elevated and serum HBV DNA level decreased（P0.01） and no obvious side effects were observed in both groups.Conclusion Adefovir dipivoxil in combination with reduced glutathione is effective and safe for treatment of chronic severe hepatitis B patients,whorthy of popularization.

关 键 词：重型乙型肝炎 还原型谷胱甘肽 阿德福韦酯 

分 类 号：R512.62[医药卫生—内科学]