复方消斑灵对创伤性瘢痕作用的实验研究  

Effects of Compound Xiaobanling on Hypertrophic Scars in a Nude Micmodle

作　　者：王毅兵[1] 于海洲 熊存全[1] 罗崇念[1] 张德昌[1] 

机构地区：[1]盐城卫生职业技术学院,江苏省盐城市224001 [2]盐城市第一人民医院烧伤整形科

出　　处：《医学理论与实践》2012年第20期2461-2462,2464,共3页The Journal of Medical Theory and Practice

摘　　要：目的:观察复方消斑灵对体外培养的成纤维细胞的胶原蛋白合成的影响,以及对水浴烫伤动物模型的作用。方法:采用光镜、电镜研究用药前、后成纤维细胞的形态学变化,以3 H-脯氨酸掺入等方法检测成纤维细胞胶原蛋白的合成,通过建立水浴烫伤动物模型,观察复方消斑灵对增生性瘢痕的作用。结果:消斑灵能明显影响成纤维细胞的超微结构,抑制胶原蛋白的合成,并呈量效关系;在大鼠水浴烫伤实验中复方消斑灵可抑制瘢痕增生,而且大剂量使用未发现药物毒性。结论:复方消斑灵对创伤性瘢痕有良好的治疗作用。Objective：To observe the effect of xiaobanling（XBL） on the fibroblast collagen biosynthesis in vitro culture and on the hypertrophic scars in a nude mice model.Methods：Light microscope（LM） and electron microscope（EM） were employed to study the morphological changes in fibroblast before and after the application of XBL.The fibroblast collagen synthesis was assayed by 3H-proline incorporation.A nude mice model with hypertrophic scar was established for observing the effect of XBL given by local injection.Results：It was found that compound XBL could significantly affect the ultrastructure of fibroblast and inhibit its collagen synthesis in vitro culture（P0.01） in a manner of dose-effect relationship.The test of aqueous bath scars in rats could inhibit the proliferation of scar without any toxic effect.Conclusion：The compound XBL have a good effect on hypertrophic scars.

关 键 词：复方消斑灵 创伤性瘢痕 胶原蛋白 成纤维细胞 

分 类 号：R64[医药卫生—外科学]