两种剂量肺表面活性物质联合鼻塞持续正压通气治疗新生儿呼吸窘迫综合征疗效观察  

The Clinical Effect of Two Different Doses of Pulmonary Surfactant Combined with NCPAP in Newborns with Respiratory Distress Syndrome

作　　者：许红[1] 

机构地区：[1]安徽省宿州市立医院儿科,安徽宿州234000

出　　处：《儿科药学杂志》2012年第11期9-11,共3页Journal of Pediatric Pharmacy

摘　　要：目的:研究两种剂量的肺表面活性物质联合鼻塞持续正压通气(nCPAP)治疗新生儿呼吸窘迫综合征(RDS)的临床疗效。方法:将2009年1月至2012年1月我院新生儿科收治的64例RDS患儿随机分为观察组和对照组各32例,两组均给予nCPAP进行治疗,并且观察组给予肺表面活性物质100 mg/kg气管内给药,对照组给予肺表面活性物质200 mg/kg气管内给药,比较两种治疗方法的临床疗效。结果:两组患儿在机械通气率、脑室内出血率及辅助通气时间、吸氧时间、住院天数等方面比较差异均无统计学意义(P>0.05),两组患儿72 h内PaO2、PaCO2、a/APO2、PaO2/FiO2等指标比较差异均无统计学意义(P>0.05)。结论:肺表面活性物质100 mg/kg和200 mg/kg联合nCPAP治疗RDS均能改善患儿的临床症状,减少并发症及死亡的发生,并且两种剂量的疗效差异无统计学意义。Objective： To study the clinical effect of two different doses of pulmonary surfactant combined with nasal continuous positive airway pressure （nCPAP） in newborns with respiratory distress syndrome （RDS）. Methods： Sixty four cases of RDS were randomly divided into an observation group and a control group from January 2009 to January 2012 in Suzhou Municipal Hospital. Both groups were treated with nCPAP, and the observation group was given 100 mg/kg of pulmonary surfactant with endotracheal administration, the control group was given 200 mg/kg of Curosurf with endotracheal administration. The clinical efficacy of the two groups was compared. Results： In both groups the differences in the mechanical ventilation rate, intraventricular hemorrhage rate, duration of assisted ventilation, oxygen time and length of hospital stay were not significant （P〉0.05）. There were no statistical differences in PaO2, PaCO2, a/APO2, PaOJFiO2 index within 72 hours in the two groups of children （ P〉0.05 ）. Conclusions： Curosurf of 100 mg/kg or 200 mg/kg combined with nCPAP in newborns with RDS can improve children＇ s clinical symptoms, reduce complications and death, the efficacy of the two treatments has no obvious difference.

关 键 词：肺表面活性物质 呼吸窘迫综合征 鼻塞持续正压通气 

分 类 号：R722.1[医药卫生—儿科]