Catalyst free synthesis of fused pyrido[2,3-d]pyrimidines and pyrazolo[3,4-b]pyridines in water  

作　　者：Abbas Rahmati Zahra Khalesi 

机构地区：[1]Department of Chemistry,University of Isfahan,P.O.Box 81746,73441 Isfahan,Iran

出　　处：《Chinese Chemical Letters》2012年第10期1149-1152,共4页中国化学快报（英文版）

基　　金：the financial support of the Research Council of the University of Isfahan

摘　　要：A one-pot, three-component condensation reaction of an aldehyde, benzoyl acetonitrile （3-oxo-3-phenylpropane nitrile） and 6- amino-1,3-dimethylpyrimidine-2,4（1H,3H）-dione or 3-methyl-l-phenyl-lH-pyrazol-5-amine in water to give fused pyrido[2,3- d]pyrimidines and pyrazolo[3,4-b]pyridines in high yields without any catalyst, is described.A one-pot, three-component condensation reaction of an aldehyde, benzoyl acetonitrile （3-oxo-3-phenylpropane nitrile） and 6- amino-1,3-dimethylpyrimidine-2,4（1H,3H）-dione or 3-methyl-l-phenyl-lH-pyrazol-5-amine in water to give fused pyrido[2,3- d]pyrimidines and pyrazolo[3,4-b]pyridines in high yields without any catalyst, is described.

关 键 词：AMINOPYRAZOLE Aqueous media 3-Methyl-l-phenyl-lH-pyrazol-5-amine Pyrazolo[3 4-b]pyridine 

分 类 号：O626.41[理学—有机化学]