中老年男性血清睾酮与代谢综合征的关系  

The relationship between serum testosterone and metabolic syndrome in middle-aged and elderly men

作　　者：乔薇[1] 李靖[1] 冯昕[1] 李瑛[1] 黄静[1] 钱端[1] 

机构地区：[1]中日友好医院干部保健病房,北京100029

出　　处：《中国综合临床》2012年第11期1180-1183,共4页Clinical Medicine of China

摘　　要：目的探讨中老年男性代谢综合征（MS）患者血清睾酮下降的原因。方法选取45～83岁的中老年男性56例为研究对象，分别测量其血压、身高、体质量，计算体质量指数（BMI），检测空腹状态下生化指标[血糖（FBG）、总胆固醇（Tc）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL．C）、高密度脂蛋白胆固醇（HDL—C）]、空腹胰岛素（FIN）及血清睾酮，并用稳态公式（HOMA）计算胰岛素抵抗指数（HOMA—IR）。根据CDS建议的MS诊断标准，将研究对象分为MS组及非MS组，分析睾酮浓度与各指标的关系。结果中老年男性MS组血清睾酮浓度明显低于非Ms组[（9．97±3．87）nmol／L与（13．73±3．93）nmol／L，t=3．337，P〈0．01]，多因素回归分析显示，血清睾酮浓度与年龄、腰围、HOMA—IR呈负相关（回归系数分别为-0．214、-0．329、-0．317，标准回归系数分别为-0．730、-0．597、-0．313，t值分别为-5．833、-4．681、-2．686，P均〈0．01）。结论中老年男性MS患者血清睾酮浓度下降，血清睾酮浓度与年龄、腰围、胰岛素抵抗密切相关。Objective To explore the causes for descending of the serum testosterone （T） in middle- aged and elderly men with metabolic syndrome （MS）. Methods Fifty-six male patients aged between 45 and 83 years old were investigated. Blood pressure, height and weight were measured, and body mass index （BMI） was calculated. Biochemical indice in fasting state [ fasting blood sugar （ FBG ）, total cholesterol （ TC ）, triglycerides （TG）, low-density lipoprotein cholesterol （LDL-C）, high-density lipoprotein cholesterol （HDL-C） ], fasting insulin （ FIN）, and the level of serum testosterone ） were detected. An insulin resistance index （IR） was calculated using homeostasis model assessment （HOMA）. Participants were divided into the MS group and the non-MS group according to CDS diagnostic standard. The relationships between the level of serum Testosterone and each index were analyzed. Results The level of serum Testosterone was significantly lower in the MS group than that in the non-MS group [ （9. 97 ~ 3.87 ） nmol/L vs. （ 13.73 ~ 3.93 ） nmol/L, t = 3. 337, P 〈 O. O1 ]. Multiple regression analysis showed that the level of serum testooterone was negatively correlated with age,waist circumference and HOMA-IR （ regression coefficients： - 0. 214, - 0. 329, - 0. 317; standardized regression coefficients ： - 0. 730, - O. 597, - 0. 313 ; t = - 5. 833, - 4. 681, - 2. 686 respctively ; P 〈 0. 01 ）. Conclusion The level of serum testosterone descends in middle-aged and elderly men with MS. The level of serum testosterone is closely related to a^e. waist circumference and insulin resistance

关 键 词：睾酮 代谢综合征 男性 老年人 

分 类 号：R589[医药卫生—内分泌]