克林霉素注射液致急性肾衰竭21例临床分析  

Clinical analysis of 21 patients with acute renal failure due to clindamycin injection

作　　者：张颖[1] 杨晶[1] 孙京华[1] 蒋甘孺[1] 李胜开[1] 尹忠诚[1] 

机构地区：[1]徐州医学院附属医院肾内科,江苏徐州221002

出　　处：《徐州医学院学报》2012年第8期521-523,共3页Acta Academiae Medicinae Xuzhou

摘　　要：目的探讨克林霉素注射液引起急性肾衰竭（ARF）的临床特点、治疗及预后。方法对21例克林霉素注射液引起ARF患者进行回顾性分析。结果21例患者中13例表现为全程肉眼血尿，13例表现为少尿或无尿。14例检查发现血尿、蛋白尿、白细胞尿。患者发病时血肌酐（SCr）值男性与女性之间差异无统计学意义（P〉0．05），SCr水平与肾功能恢复时间呈正相关（r=0．778，P〈0．01）。21例患者经过能量支持、维持水电酸碱平衡或合并应用地塞米松、血液透析等治疗后尿量及肾功能均恢复正常。治疗后SCr与治疗前相比差异有统计学意义（P〈0．01）。结论克林霉素注射液可引起少尿、无尿、血尿、蛋白尿、白细胞尿，可导致急性肾衰竭。克林霉素注射液所致急性肾衰竭立即停药及时治疗预后较好。Objective To investigate the clinical characteristics, treatment and prognosis in patients with acute renal failure （ARF） due to clindamyein injection. Methods We analyzed retrospectively the clinical characteristics, treatment and prognosis in 21 patients with ARF due to elindamycin injection. Results 13 of 21 patients presented a symptom of gross total hematuria. 13 patients presented oliguresis or anuria symptoms. Urinalysis of 14 patients showed hematuria, proteinuria, leukoeytes in urine. There was no statistical significance between male and female in original serum creatinine （P 〉 0.05 ）. Recovery days of renal function was positively correlated with original serum ereatinine （ r = 0. 778 ,P 〈 0.01 ）. The urine volume and renal function of 21 patients returned to normal after stopping use of clindamycin injection, maintaining water and electrolyte balance, using diuretic drugs, using dexamethasone injection and hemodialysis treatment. There was statistical significance in serum creatinine before and after the theatment （P 〈 0.01 ）. Conclusions Clindamycin injection can lead to oliguresis, anuria, hematuria, proteinuria, leukocytes in urine and acute renal failure. The patients with ARF due to clindamycin injection had better prognosis after stopping use of clindamycin injection immediately and being treated promptly.

关 键 词：克林霉素 急性肾衰竭 临床分析 

分 类 号：R692.5[医药卫生—泌尿科学]