血管内皮生长因子在自然流产胚胎和人工流产胚胎中的表达  

Expression of Vascular Endothelial Growth Factor in Embryos of Spontaneous Abortion and Induced Abortion

作　　者：袁秀英[1] 韩临晓[1] 刘燕燕[1] 黄丽娥[1] 刘小媚[1] 

机构地区：[1]广东省东莞市石龙人民医院,广东东莞523320

出　　处：《实用预防医学》2012年第10期1527-1529,共3页Practical Preventive Medicine

摘　　要：目的探讨自然流产胚胎和人工流产胚胎中血管内皮生长因子(VEGF)表达量的差异。方法按照孕周分组,采用免疫组化法检测30例自然流产胚胎(病例组)绒毛组织中VEGF的表达,同时收集50例人工流产的胚胎绒毛组织(对照组)检测VEGF进行对照分析研究。结果在不同的孕周,病例组其VEGF的表达量均较对照组降低,且对照组VEGF的表达量随着孕周的增加而增加,在病例组中却没有这样的趋势。结论自然流产的胚胎组织与同孕周的人工流产的胚胎组织相比其VEGF表达量下降,提示VEGF表达量下降可能与自然流产相关。Objective To explore the expression differences of vascular endothelial growth factor（VEGF） in embryos of spontaneous abortion and induced abortion. Methods According to gestational age,80 women with abortion were divided into two groups.Immunohistochemistry was used to observe the expression of VEGF in embryonic villi of 30 cases of spontaneous abortion（patient group） and 50 cases of induced abortion（control group）. Results Among different gestational ages,the expression of VEGF in patient group was lower than that of control group.The expression of VEGF in control group was increased with the gestational age,but the same trend was not observed in patient group. Conclusions Among the same gestational age,the expression of VEGF in embryonic villi of spontaneous abortion was declined as compared with that in induced abortion.The decreased expression of VEGF may be associated with spontaneous abortion.

关 键 词：自然流产 血管内皮生长因子 孕周 

分 类 号：R714.21[医药卫生—妇产科学]