血甘油三酯、尿酸对非酒精性脂肪性肝病患者血清肿瘤坏死因子α、白介素6及胰岛素抵抗的影响  被引量:8

The influence of serum levels of triglicerides and uric acids on insulin resistance and tumor necrosis factor alpha and interleukin-6 in patients with nonalcoholic fatty liver disease

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作  者:白秀平[1] 赵宝珍[1] 李爱卿[1] 高敏[1] 李兴[1] 

机构地区:[1]山西医科大学第二医院内分泌科,山西太原030001

出  处:《胃肠病学和肝病学杂志》2012年第10期936-938,共3页Chinese Journal of Gastroenterology and Hepatology

基  金:山西医科大学第二医院博士启动基金(20080412)

摘  要:目的观察血甘油三酯(TG)、尿酸(UA)对非酒精性脂肪性肝病(NAFLD)患者血清肿瘤坏死因子α(TNF-α)、白介素6(IL-6)及胰岛素抵抗(IR)的影响。方法从我院就诊经彩色超声诊断的脂肪肝患者中,依血TG水平分为3组,即血TG正常组(NT)、仅血TG升高组(HT组)、血TG合并UA升高组(HTU组),以血TG正常的非脂肪肝人群做对照组(Control)。测各组血清胰岛素、TNF-α、IL-6、血糖,以胰岛素抵抗指数(HOMA-IR)评价IR。结果与Control相比,NT、HT组TNF-α、IL-6、HOMA-IR均无明显增高(P>0.05);HTU组IL-6及HOMA-IR明显增高[IL-6,HTU:135.19(90.27~164.24)ng/mL vs Control:61.6(53.53~79.69)ng/mL;HOMA-IR,HTU:2.34±0.53 vs Control:1.00±0.81,P<0.01],TNF-α无明显增高(P>0.05);相关分析表明,血TG与HO-MA-IR呈明显正相关(r=0.428,P<0.01)。结论 NAFLD患者是否发生IR及IL-6、TNF-α的变化可能受不同TG水平的影响。Objective To investigate the influence of serum triglicerides and uric acid on insulin resistance(IR),tumor necrosis factor alpha(TNF-α) and interleukin-6(IL-6) in patients with nonalcoholic fatty liver disease(NAFLD).Methods Patients diagnosed with NAFLD were divided into 3 groups: normal serum TG and UA group(NT group),hypertriglyceridemia and normal serum uric acid group(HT group),hypertriglyceridemia and hyperuricemia group(HTU group),subjects without fatty liver disease and abnormal TG as controls.Serum insulin,glucose,TNF-α,IL-6 were determined.The influence of serum TG,UA on IR,TNF-α and IL-6 in NAFLD patients were analyzed,IR was indicated by HOMA-IR.Results TNF-α,IL-6 and HOMA-IR were not increased significantly in NT and HT group compared with control group(P>0.05),but these indexes were increased significantly in HTU group.Correlation analysis showed serum TG was correlated independently with HOMA-IR(r=0.428,P<0.05).Conclusions Hypertriglyceridemia is an independent risk factor for the development of IR in NAFLD patients.Hypertriglyceridemia and hyperuricemia may be related to the levels of TNF-α and IL-6.

关 键 词:甘油三酯 尿酸 胰岛素抵抗 肿瘤坏死因子Α 白介素-6 非酒精性脂肪性肝病 

分 类 号:R589.2[医药卫生—内分泌]

 

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