联合使用阿托伐他汀和贝那普利对IgA肾病蛋白尿的影响  

Effects of Atorvastatin in Combination with Benazepril on Proteinuria in Patients with IgA Nephropa-thy

作　　者：曾石养[1] 苏海燕[1] 薛志强[1] 

机构地区：[1]广东省暨南大学医学院附属清远医院、广东省清远市人民医院肾内科,清远511515

出　　处：《临床肾脏病杂志》2012年第10期456-458,共3页Journal Of Clinical Nephrology

摘　　要：目的 探讨阿托伐他汀联合贝那普利治疗对IgA肾病患者蛋白尿的影响。方法 将62例IgA肾病患者随机分为对照组30例，应用贝那普利治疗；治疗组32例，应用阿托伐他汀联合贝那普利治疗；2组疗程均为6个月，比较2组治疗前、后，血压、总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、尿蛋白（U-pro）、丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、肌酸激酶（CK）、肌酸激酶同工酶（CK-MB）等指标的变化情况。结果 治疗组治疗后6个月，TC、LDL-C、L卜Pro等指标明显下降，与对照组比较有统计学差异（P〈0．05）；而2组治疗前、后比较，TG、HDL-C、ALT、AST、CK、CK-MB均无统计学差异（P〉0．05）。结论 阿托伐他汀联合贝那普利，能有效降低IgA肾病患者的TC、LDL-C、U-pro水平。Objective To investigate the therapeutic effects of atorvastatin combined with benazepril on proteinuria in patients with IgA nephropathy. Methods Sixty-two patients with IgA ne- phropathy were divided randomly into two groups：control group （n = 30） given benazepril, and experi- mental group （n= 32） given atorvastatin and benazepril. The patients in both two groups were give treatment for 6 months, and the indexes of total blood pressure, cholesterol （TC）, triglyceride （TG）, low density lipoprotein cholesterol （LDL-C）, high density lipoprotein cholesterol （HDL-C）, urinary protein （U-pro）, alaninetransaminase （ALT）, aspartate aminotransferase （AST）, creatine kinase （CK） and creatine kinase isoenzyme （CK-MB） were measured before and after treatment. Results After treatment for 6 months, the indexes of TC, LDL-C and U-Pro in experimental group were decreased more significantly than in control group （P〈0. 05）, and there were no significant changes in TG, HDL-C,ALT,AST,CK and CK-MB before and after treatment in both two groups （P〉0. 05）. Con- clusions Atorvastatin in combination with benazepril can more effectively decrease TC, LDL-C and U- pro levels in patients with IgA nephropathy.

关 键 词：IGA肾病 蛋白尿 病理学 临床 

分 类 号：R586[医药卫生—内分泌]