气虚体质及CYP2E1基因多态性与抗结核药物性肝损伤的关系  

Relationship among Qi-deficiency constitution and CYP2E1 gene polymorphisms and anti-tuberculosis drug-induced hepatitis

作　　者：周敏[1] 毛敏杰[1] 朱敏[1] 李凫坚[1] 尹良胜[1] 李锋[1] 

机构地区：[1]杭州市红十字会医院结核科,浙江杭州310003

出　　处：《中西医结合肝病杂志》2012年第5期265-267,共3页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：杭州市科技发展计划(No.20091233Q24)

摘　　要：目的:归纳总结抗结核药物性肝损伤患者常见中医体质,阐明其中气虚体质与CYP2E1基因多态性的内在关联,及其在药物性肝损伤中的防治作用。方法:入选病例填写中医体质辨识量表进行中医体质类型分类,运用多聚酶链反应技术(PCR法)检测CYP2E1基因多态性,分析抗结核药物性肝损伤患者临床常见体质,比较其中气虚体质患者基因频率的差异。结果:肝损伤组患者气虚体质分布频率明显高于对照组(P<0.05),由于9种类型中医体质在肝损伤组及对照组患者中均有体现,影响不同体质患者样本量分布,气虚体质样本量少,与CYP 2E1基因型分布频率的关联及其差异不能进行有意义的比较。结论:气虚体质与抗结核药物性肝损伤密切相关,对指导结核病的个体化治疗,预防肝损伤有重要意义。Objective：To analyse the distribution feature of the Chinese medicine constitution types in patients of anti-tuberculosis drug-induced hepatitis,and interpret the correlation of Qi-deficiency constitution with CYP2E1 gene polymorphisms,for exploring a new way of prevention and cure of the diseases.Methods：The Chinese medicine constitution type of the patients was judged by constitution identifying chart,and their genotype of CYP2E1 was detected by the technic of polymerase chain reaction for analyzing the distribution feature of the constitution types and comparing the difference of distribution frequency of Qi-deficiency constitution and genes.Results：As compared with the control group,the frequence of Qi-deficiency constitution in hepatic lesion group was significant higher（P〈0.05）.There was no singificance in the correlation of Qi-deficiency constitution with CYP2E1 gene polymorphisms because of hypo-sample size.Conclusion：Qi-deficiency constitution shows connection with anti-tuberculosis drug-induced hepatitis.It is significant to help make the treatment individualized and reduce incidence of the disease.

关 键 词：结核 药物性肝损害 中医体质 细胞色素P450 基因多态性 

分 类 号：R595.3[医药卫生—内科学]