黄芩苷镧(Ⅲ)、钇(Ⅲ)配合物的合成及生物活性研究  

Research on Synthesis and Biological Activities of Baicalin-La( Ⅲ)、Y(Ⅲ) Complexes

作　　者：张齐雄[1] 施伦勇[1] 刘衍季[1] 

机构地区：[1]西南大学药学院,重庆400715

出　　处：《天然产物研究与开发》2012年第10期1398-1401,共4页Natural Product Research and Development

基　　金：国家级大学生创新创业训练计划(201210635074)

摘　　要：改进以往反应条件,合成了黄芩苷镧(Ⅲ)、黄芩苷钇(Ⅲ)配合物,利用IR、UV、LC-MS和金属元素含量测定对配合物进行了表征。采用MTT法分别考察了两种新化合物的抑菌活性(金黄色葡萄球菌、大肠杆菌、枯草芽孢杆菌、沙门氏菌、白色念珠菌)和抗肿瘤活性(A549、HepG2),采用灌胃法考察化合物对小鼠的急性毒性。结果表明:黄芩苷在与金属配合后,结构表征发生了一定的变化,配合物无金属离子毒性反应,并且其抑菌、抗肿瘤作用均显示出黄芩苷镧>黄芩苷钇>黄芩苷。Baicalin-La（Ⅲ） .Y（Ⅲ） complexes was synthesized by a new method and characterized by IR.UV.LC-MS and metal elemental analysis. Their antimicrobial activity （ Staphylococcus a ureus, hay-bacillus, Escherichia coli, salmonella and Candida albicans） and antitumor activity （A549 and HepG2 cells） were tested and compared with baicalin through MTT. The resuh indicated that the structure of baicalin-La, baicalin-Y complex has changed greatly comparing with baicalin. The acute toxicity testing of mice showed that the compounds had no metal ion toxicity. The bioactivities about antimicrobial efficacy, antitumor efficacy were best for baicalin-La,secondary for baiealin-Y and worst for baicalin.

关 键 词：稀土金属 黄芩苷 配合物 抗菌 抗肿瘤 

分 类 号：R9[医药卫生—药学]