纤克颗粒对肺纤维化大鼠模型病理形态学的影响研究  

Research on the Effect of Xiankekeli on Pathomorphological Changes Influenced in Pulmonary Fibrosis Rats

作　　者：李霞[1] 宫晓燕[2] 杨光[3] 王爽[3] 隋晓丹[3] 岳冬辉[3] 

机构地区：[1]长春中医药大学基础医学院,吉林长春130117 [2]长春中医药大学第一临床学院,吉林长春130117 [3]长春中医药大学博士研究生,吉林长春130117

出　　处：《时珍国医国药》2012年第10期2449-2451,共3页Lishizhen Medicine and Materia Medica Research

基　　金：吉林省自然科学基金(No.201015206);吉林省中医药管理局中医药科技项目(No.2010-073)

摘　　要：目的观察纤克颗粒对平阳霉素诱导的肺纤维化模型病理形态学的影响。方法 wistar大鼠分为6组,正常对照组、模型组、泼尼松组、纤克高剂量组、纤克中剂量组和纤克低剂量组。分别于连续给药的第7天、14天和28天后,取肺组织行HE染色、Masson染色,确定肺泡炎和肺纤维化程度。结果肺泡炎积分,与模型组相比较,第7天,泼尼松组及纤克高、中剂量组具有显著差异(P<0.01或P<0.05);第14天,泼尼松组及纤克高剂量组具有显著差异(P<0.01或P<0.05);第28天,纤克高剂量组具有显著差异(P<0.05)。肺纤维化积分,与模型组相比较,第7天、14天,泼尼松组及纤克高、中剂量组具有显著差异(P<0.05或P<0.01);第28天,泼尼松组及纤克各剂量组均有显著差异(P<0.05或P<0.01)。结论纤克颗粒明显减轻肺纤维化模型大鼠的肺泡炎及肺纤维化程度,具有防治肺纤维化的作用。Objective To observe the effect of Xiankekeli on the patholagical changes in pulmonary fibrosis rats by Bleomycin AS. Methods 108 Wistar rats were divided into 6 groups in random： control group, model group, prednisone group, high- dose Xianke group（ HD group） ,medium - dose Xianke group（ MD group） and low dose Xianke group（ LD group）. After continous ad- ministration,lung tissues dyed by HE and Masson were observed. Results There had difference in the degree of alveolar catarrh in prednisone group, HD group and MD group on the 7th day compared with model group （ P 〈 0.01 or P 〈 0.05 ） ; the difference be- tween prednisone group and HD group was significant on the 14th day （ P 〈 0.01 or P 〈 0.05 ） and on the 28th clay （ P 〈 0.05 ）. There also had significant difference in the degree of pulmonary fibrosis in prednisone group, HD group and MD group on the 7th day and the 14th day compared with modle group（P 〈0.05 or P 〈0.01 ） ;prednisone group and each Xianke group were signifi- cantly different on the 28th day（ P 〈 0.05 or P 〈 0.01 ）. Conclusion Xiankekeli can alleviate alveolar catarrh and pulmonary fi- brosis in pulmonary fibrosis rats.

关 键 词：纤克颗粒 肺纤维化 病理形态学 

分 类 号：R285.5[医药卫生—中药学]