柴芩承气汤治疗重症急性胰腺炎是药动学-药效学关系研究更好的侯选对象  

Radix Bupleuri-Radix Scutellariae Purgative Decoction is Better for Study on Relationship of Pharmacokinetics-pharmacodynamics on Treating Severe Acute Pancreatitis

作　　者：朱林[1] 陈光远[1] 

机构地区：[1]四川大学华西医院,四川成都610041

出　　处：《中医药导报》2012年第10期5-8,共4页Guiding Journal of Traditional Chinese Medicine and Pharmacy

摘　　要：重症急性胰腺炎(severe acute pancreatitis,SAP)为凶险危重难治的急腹症,目前国际上病死率高达25%,华西医院选用柴芩承气汤治疗病死率仅10.77%。之前,药物动力学研究选择冠心II号治疗稳定性心绞痛被认为是研究方剂药动学的良好方剂,但难以取得随机双盲对照的确切疗效。比较之下,柴芩承气汤治疗SAP是研究确有疗效方剂药动学-药效学关系的更好对象。本文论述了柴芩承气汤在SAP的药动学-胃肠动力关系研究的科学依据。Severe acute pancreatitis （SAP） is a kind of critical and refractory surgical abdomen, the case fatality rate of which is 25%. We apply Radix Bupleuri-Radix Scutellariae Purgative Decoction for the treatment on severe acute pancreatitis and the case fatality rate is 10.77%. We treated stable angina with Guanxin II, which we considered as a better formula for the study on relationship of pharmacokinetics-pharmacodynamics, but it was difficult to get randomized double-blind effect. Compared with Guanxin II, Radix Bupleuri-Radix Scutellariae Purgative Decoction is better for study on relationship of phar- macokinetics-pharmacodynamics on treating SPA. This paper discuses the scientific basis for Radix Bupleuri-Radix Scutellariae Purgative Decoction on the pharmacokinetics-gastrointestinal motility by treating SPA.

关 键 词：柴芩承气汤 重症急性胰腺炎 药动-药效关系 

分 类 号：R256.3[医药卫生—中医内科学]