四溴及四碘荧光素二乙酸酯急性毒性及对S180作用的观察  

Acute Toxicities and the Inhibitory Effects of Tetrabromofluorescein Diacetate and Tetraiodofluorescein Diacetate on the Transplanted Mouse Tumours Sl80 in Mice

作　　者：王达纬[1] 孙以方[1] 吴勇杰[1] 张培棪 王流芳[2] 

机构地区：[1]兰州医学院药理教研室 [2]兰州大学化学系

出　　处：《兰州医学院学报》1990年第2期65-68,共4页Journal of Lanzhou Medical College

摘　　要：本文报道四溴荧光素二乙酸酯(25号)及四碘荧光素二乙酸酯(24号)小鼠单次腹腔注射LD_50分别为1047.1 mg/kg,608.64mg/kg.以LD_50 1/10剂量,每日1次腹腔注射,连续7次,对小鼠移植性肿瘤S180有抑制作用,抑瘤率分别为31%,19%.实验中未见小鼠有脱毛现象.In this article was reported 50%lethal dose of Tetrabromofluorescein diacetate after intraperitoneal in- jections singularly in mice was 1047.10+88.Olmg/kg;50%lethal dose of Tetraiodofluorescein diacetate was 608.64+49.53mg/kg. The inhibitory effects of Tetrabromofluorescein diacetate and Tetraiodofluorescein diacetate on the transplantedmouse tumours Sarcoma 180 after intraperitoneal injections in mice were as follows: Name Dose Inhibitory rate Tetrabromofluorescein diacetate 100mg/kg 31% Tetraiodofluorescein diacetate 60mg/kg 19% In the mean time,alopecia universalis could not be observed.

关 键 词：四溴荧光素 二乙酸酯 急性毒性 S180瘤株 抑瘤率 

分 类 号：R962[医药卫生—药理学]