戊脉安体外对小鼠L_(1210)白血病细胞杀伤作用的观察  

The Effect of Verapamil on L_(1210)Leukemia Cells in Vitro

作　　者：邵宁生[1] 金大年[1] 张培棪 梁重栋 

机构地区：[1]兰州医学院药理教研室

出　　处：《兰州医学院学报》1990年第2期78-80,共3页Journal of Lanzhou Medical College

摘　　要：本文采用体外培养的L_(1210)细胞株,研究了戊脉安的体外抗肿瘤作用.发现戊脉安对L_1210细胞的生长有一定的抑制作用,且呈剂量相关,并能显著降低L_1210细胞的分裂指数.其抗肮瘤作用与细胞外钙离子浓度无关.The effect of verapamil on L_(1210)leukemia cells in vitro were studied.The results showed that verapamil had certain dose-related inhibitory effects on the growth of L_(1210)cells and the mitotic index of L_(1210)cells.No relationship was observed between the antitumour effects and extracellular Ca^(2+)concentrations.

关 键 词：L1210细胞 分裂指数 抗瘤活性 细胞外钙 

分 类 号：R979.1[医药卫生—药品]