戊脉安对小鼠L_(1210)白血病细胞作用的超微结构观察  

Influence of Verapamil on Ultrastructure of Murine Leukemia L_(1210)Cells

作　　者：邵宁生[1] 张培棪 梁重栋 裴正礼[1] 

机构地区：[1]兰州医学院药理教研室

出　　处：《兰州医学院学报》1990年第3期129-130,共2页Journal of Lanzhou Medical College

摘　　要：本文观察了戊脉安(10.0μg/ml)对小鼠L_(1210)白血病细胞体外作用的超微结构变化。结果发现,药物作用一段时间后,细胞超微结构变化明显。药物作用24小时,可见线粒体肿胀、破裂及嵴消失,细胞核膜皱缩;作用48小时,可见1/7～1/8细胞破碎死亡,大部分线粒体膜破裂,粗面内质网扩张呈囊泡化。部分核出现核质溶解、核固缩和核破裂等现象。实验组A型病毒颗粒分布与对照组差别不大。The ultrastructural changes of leukmia L_(1210) cells treated by verapamil (10.0μg/ml)were observed in this report. The changes of L_(1210)cells 24 h after verapamil were severe swelling of some mitochondria with fracture and disappearance of inner cristae. Complex folds of nuclear membrane were also seen. 48 h results showed that 1/8～1/7 cells were dead with pyknosis, karyorrhexis, karyolysis. Most mitochondria were severe frac. tured.

关 键 词：戊脉安 白血病细胞 超微结构 白血病 

分 类 号：R397－33[医药卫生—基础医学]