四川省细菌耐药监测网2011年川南地区细菌耐药性监测数据分析  

Sichuan Provincial of antimicrobial Resistant Investigation Net 2011 annual report:Bacterial drug resistance surveillance in South Sichuan

作　　者：张肃川 梁定伟 何小平[1] 

机构地区：[1]四川省自贡市第一人民医院检验科,四川自贡643000

出　　处：《实用医院临床杂志》2012年第6期115-120,共6页Practical Journal of Clinical Medicine

摘　　要：目的统计分析四川省川南地区细菌耐药监测网成员单位2011年度细菌分布及耐药情况,为我省临床抗菌药物合理应用提供依据。方法四川省川南地区细菌耐药监测网各成员单位按照监测方案要求,进行目标细菌收集、鉴定和药敏实验,并及时将数据上报四川省临床检验中心。依据美国实验室与标准化研究所(CLSI)2010年标准,采用WHONET软件(5.5版本),对2011年1～12月监测资料进行分析总结。结果共收集细菌10022株,其中革兰阴性菌7657株,占76.4%;革兰阳性菌2365株,占23.6%。革兰阳性菌以金黄色葡萄球菌、凝固酶阴性葡萄球菌为主,占71.7%;其次为肠球菌,占18.9%;链球菌占9%,对万古霉素、头孢哌酮/舒巴坦、亚胺培南等较敏感。革兰阴性菌前五位的为:大肠埃希菌占34.4%、肺炎克雷伯菌占19.2%、铜绿假单胞菌占12.8%、鲍曼不动杆菌占11.2%、阴沟肠杆菌占6.5%。结论川南地区与全省情况一致,临床标本培养分离的病原菌以革兰阴性菌为主,菌株呈现多重耐药性。临床应加强对怀疑感染病人在抗生素使用前,尽量留取相应标本做细菌培养,以明确感染病原菌及其耐药情况,尽早准确合理应用抗生素,提高治愈率。Objective Investigate the distribution and the drug resistance of the pathogenic bacteria isolates from clinical specimen and provide the reasonable usage of antibiotics in clinical treatment. Methods The identity and drug sensitivity test of 10022 isolates of pathogenic bacteria were analyzed retrospectively. Results 10022 strains were isolated, which included 7657 （ 76.4% ） Gram-negative strains, and 2365 （ 23.6% ） Gram-positive strains. The main Gram-positive bacteria were staphylococcus aureus, eoagu- lase negative staphylococci,which were sensitive to vaneomycin, cefoperazone, sulbactam and imipenem. The first occupying five Gram- negative bacteria were Eseherichia coli（ 34.4% ） , Klebsiella pneumoniae （ 19.2% ） , Pseudomonas aeruginosa （ 12.8% ） , Acinetobacter baumannii（ 11.2% ） and Enterobacter cloacae （6.5%）. Conclusion The positive strains isolated from clinical specimen had multiple resistance to antibiotics. Therefore, the bacterial culture and identification must be done for antibiotics reasonable using.

关 键 词：细菌 耐药 革兰阴性菌 革兰阳性菌 药敏试验 

分 类 号：R370[医药卫生—病原生物学] R962[医药卫生—基础医学]