阿片类药物引起痛觉过敏的脊髓机制  

Mechanisms of opioid-induced hyperalgesia in the spinal cord level

作　　者：雷洪伊[1] 徐世元[1] 

机构地区：[1]南方医科大学珠江医院麻醉科,广州510282

出　　处：《国际麻醉学与复苏杂志》2012年第11期777-779,794,共4页International Journal of Anesthesiology and Resuscitation

基　　金：2010年度贝朗麻醉科学研究基金

摘　　要：背景阿片类药物引起的痛觉过敏（opioid-induced hyperalgesia，OIH）日益引起关注，其机制有待深入研究。目的论述脊髓水平OIH的机制，以供临床研究防治此类痛觉过敏参考。内容就脊髓水平受体通路、信号转导路径及神经肽等方面，论述OIH的机制。趋向脊髓水平多种途径参与OIH，值得进一步研究。Background Opioid-induced hyperalgesia has received increasing attention, and the mechanisms need further investigation. Objective To expound some possible mechanisms of opioid-induced hyperalgesia in the spinal cord level, which may offer some methods for prevention of the hyperalgesia in clinic. Content This review provides some information about opioid- induced hyperalgesia in the spinal cord level, such as the receptors pathway, signal transduction pathway, neuropeptide and so on. Trend The detailed mechanism of opioid-induced hyperalgesia in the spinal cord level needs further study.

关 键 词：阿片类药物 脊髓 痛觉过敏 

分 类 号：R614[医药卫生—麻醉学]