厚朴酚纳米胶束的制备及性能研究  

Preparation and Properties of Magnolol Nano-micelle

作　　者：邵东旭[1] 郑冬梅[1] 张欢[1] 杨薇[1] 

机构地区：[1]琼州学院理工学院,海南三亚572022

出　　处：《琼州学院学报》2012年第5期22-25,共4页Journal of Qiongzhou University

基　　金：海南省教育厅高等学校科研资助项目(Hj2009-132)

摘　　要：以单甲氧基聚乙二醇-外消旋聚乳酸为载体制备包载厚朴酚的纳米胶束新剂型,观察胶束的形貌,测定胶束的平均粒径、载药量、药物包封率及进行体外释药实验.研究表明,所制备的厚朴酚胶束呈规则球状,胶束平均粒径达纳米级,胶束的体外释药具有缓释特性.The mPEG - PLA was applied as carder to encapsulate magnolol to form new dosage forms of nano - micelle. The shape of the nano - micelles were observed. The average size and the drug loading con - tent and encapsulation efficiency of the nano - micelles were determined. Solvent evaporation, the prepared magnolol micelles had nanosize and size distribution, they have excellent drug sustained- release behavior.

关 键 词：厚朴酚 胶束 体外释药 

分 类 号：TQ461[化学工程—制药化工]