双二茂铁基希夫碱的合成及抗菌活性  

Synthesis and antibacterial activity of bisferrocenyl Schiff bases

作　　者：柴凤兰[1,2] 宋晓寒[2] 赵彬[1] 王向宇[1] 

机构地区：[1]郑州大学工业催化研究所,河南郑州450052 [2]河南化工职业学院博士工作室,河南郑州450042

出　　处：《应用化工》2012年第10期1741-1744,共4页Applied Chemical Industry

基　　金：河南省杰出人才创新基金资助项目(0221001200)

摘　　要：利用二茂铁甲醛分别与1,2-乙二胺、1,3-丙二胺和1,4-丁二胺缩合,合成了3种双二茂铁基希夫碱,进行了生物活性实验。结果表明,3种双二茂铁基希夫碱对大肠埃希氏菌和金黄色葡萄球菌均具有较好的抗菌活性,1,3-丙二胺双缩二茂铁甲醛对金黄色葡萄球菌的抑菌能力最强,生物效价为210 U/mg(与四环素盐酸盐相比较);1,4-丁二胺双缩二茂铁甲醛对大肠埃希氏菌的抑菌能力最好,生物效价为1 058 U/mg(与四环素盐酸盐相比较)。3种双二茂铁基希夫碱对大肠埃希氏菌的抑菌能力比对金黄色葡萄球菌的抑菌能力强。Three bisferrocenyl Schiff bases were synthesized by using ferrocenecarboxaldehyde and 1,2-ethylenediamine,1,3-propanediamine and 1,4-butanediamine,the bioactivity experiments was carried out.The results showed that the Schiff bases had a better antibacterial activity against Escherichia coli and Staphylococcus aureus,respectively.Among them,The N1,N3-bis（ferrocenylmethylene）propane-1,3-diamine possessed the better antibacterial activity for Staphylococcus aureus and its biological potency was 210 U/mg（vs acheomycin）,while the antibacterial activity of N1,N4-bis（ferrocenylmethylene）butane-1,4-diamine against Escherichia coli was the most intense and its biological efficiency was 1 058 U/mg（vs acheomycin）.The antibacterial activities of the Schiff bases against Escherichia coli were the more intense than those against Staphylococcus aureus.

关 键 词：二茂铁 希夫碱 抗菌活性 

分 类 号：TQ460.3[化学工程—制药化工] O643.3[理学—物理化学]