微波合成氮杂环丁酮二硫代苯并噻唑的研究  

Study on synthesis of 4-(2-benzothiazolyldithio)-2-azetidinone under microwave irradiation

作　　者：蒋晓帆[1] 贺新[1] 

机构地区：[1]常州工程职业技术学院化工系,江苏常州213164

出　　处：《应用化工》2012年第10期1745-1746,1750,共3页Applied Chemical Industry

基　　金：2011年江苏省高等学校大学生实践创新项目(CX2011-4)

摘　　要：采用微波辐射的方法,以2-巯基苯并噻唑为次磺酸捕捉剂,对青霉素G亚砜对-甲氧基苄基酯开环生成氮杂环丁酮二硫代苯并噻唑的反应条件进行优化。结果表明,最佳的反应条件为:青霉素G亚砜对-甲氧基苄基酯、2-巯基苯并噻唑物质的摩尔比为1∶1.1,甲苯10 mL,反应温度140℃,微波辐射功率720 W,辐射时间4 min,此时产率89.80%,与普通加热反应相比,反应时间缩短至4 min。Microwave irradiation was used to the optimization of reaction conditions for the synthesis of the azetidinone disulfide from penicillin G sulfoxide p-methoxybenzyl ester with 2-mercaptobenzothiazole.The results showed that the optimal condition was as follows：the molar ratio of penicillin G sulfoxide p-methoxybenzyl ester to 2-mercaptobenzothiazole were 1∶ 1.1,the volumn of toluene is 10 mL,reaction temperature was 140 ℃,microwave power was 720 W,microwave irradiation time was 4 min.Compared to the conventional method,the yield of 4-（2-benzothiazolyldithio）-2-azetidinone was 89.80% and reaction time was shortened to 4 min.

关 键 词：青霉素G亚砜对-甲氧基苄基酯 开环 微波辐射 

分 类 号：TQ465[化学工程—制药化工]