AIDS患者与正常人CD8+CD25+、CD4+CD25+、B淋巴细胞、NK细胞与NKT细胞计数对照研究  

Comparative Study on CD8+CD25+,CD4+CD25+,B lymphocyte,NK cell and NKT cell counts between AIDs Patients and Health People

作　　者：赵磊[1] 王念跃[1] 张红梅[1] 

机构地区：[1]东南大学第二附属医院,江苏南京210003

出　　处：《中国实验诊断学》2012年第10期1857-1859,共3页Chinese Journal of Laboratory Diagnosis

摘　　要：目的方法研究AIDs患者与正常人CD8+CD25+、CD4+CD25+、B淋巴细胞、NK细胞与NKT细胞数量差异,进一步了解AIDs患者免疫功能状态。方法:将研究对象分为两组:AIDs患者组与正常对照组。分别对AIDs患者组40余份样本与正常对照组30份正常人全血样本进行CD8CD25、CD4+CD25+、B淋巴细胞、NK细胞与NKT细胞计数检测。结果与正常对照组相比,AIDs患者组CD8CD25、CD4+CD25+细胞计数显著增加,B淋巴细胞计数下降,NK细胞计数下降,P<0.05,差异具有统计学意义。NKT细胞计数下降,差异无统计学意义,P>0.05。结论 AIDs患者CD8+CD25+、CD4+CD25+细胞计数增加,B淋巴细胞与NK细胞计数下降,NKT细胞计数与正常人无显著差异。Objective Investigate on difference between CD8＋CD25＋,CD4＋CD25＋,B lymphocyte,NK cell and NKT cell counts of AIDs patients and health people to study status of immune function in AIDs patients further.Methods Divide study subjects into two groups：group of AIDs patient and health people.Perform detection of CD8＋CD25＋,CD4＋CD25＋,B lymphocyte,NK cell and NKT cell counts respectively.Results Compared with that in group of health people,CD8＋CD25＋,CD4＋CD25＋ counts of AIDs patients increase significantly（P0.05）,B lymphocyte,NK cell counts of AIDs patients decrease（P0.05）,and there is no significant difference in NKT cell counts between AIDs patients and health people.Conclusion There is significant increase in CD8＋CD25＋,CD4＋CD25＋ counts in AIDs patients,and significant decrease in B lymphocyte,NK cell counts in AIDs patients,and it is no significant difference in NKT cell counts between AIDs patients and health people.

关 键 词：AIDS患者 CD8CD25计数 CD4+CD25+计数 B淋巴细胞计数 NK细胞计数 NKT细胞计数 

分 类 号：R512.91[医药卫生—内科学]