生物可降解高聚物P3HB4HB热性能、结晶性能和力学性能研究  

THERMAL CHARACTERISTICS, CRYSTALLIZATION PROPERTIES AND METHANICAL PROPERTIES OF BIODEGRADABLE COPOLYMER P3HB4HB

作　　者：许菡[1] 孔梅梅[1] 安军[1] 宋存江[2] 王伟[1] 陈思原[1] 翁蕾[1] 李岩冬 王淑芳[1] 

机构地区：[1]药物化学生物学国家重点实验室、生物活性材料教育部重点实验室,天津300071 [2]分子微生物与技术教育部重点实验室、南开大学生命科学学院,天津300071 [3]功能高分子材料教育部重点实验室、南开大学化学学院,天津300071

出　　处：《离子交换与吸附》2012年第5期385-392,共8页Ion Exchange and Adsorption

基　　金：国家“973”计划(2012CB725204);国家自然科学基金(51073081,50830104,31070039);天津市自然科学基金(11JCYBJC09500)

摘　　要：P3HB4HB是3β-羟基丁酸酯(3HB)和4β-羟基丁酸酯(4HB)的共聚物。由微生物合成的P3HB4HB具有良好的生物相容性和生物降解性。本研究通过示差扫描热分析(DSC)研究了P3HB4HB的热性能;通过广角X-射线衍射(WAXD)分析了材料的结晶度;通过拉伸力学试验研究了材料的力学性能。结果表明,4HB含量越高,玻璃化转变温度越低,结晶温度越高,结晶度越低;P3HB4HB是一类力学性能接近于PCL或PLGA的生物高分子,通过调节4HB的含量,可以制备出具有不同力学性能的生物材料。P3HB4HB is a copolymer of 3β-hydroxybutyrate and 4β-hydroxybutyrate. P3HB4HB has excellent biocompatibility and biodegradability. The thermal characteristics were studied by means of differential scanning calorimetry （DSC）. The crystallinity of materials was investigated through the wide angle X-ray diffraction （WAXD） analysis. Mechanical properties of P3HB4HB were investigated by tensile mechanical test. All the results indicated that with the increase of the content of 4HB made the glass transition temperature decreased, crystallization temperature increased, and crystallinity of materials decreased. Additionally, mechanical properties of P3HB4HB were close to PCL or PLGA. By regulating the content of 4HB, P3HB4HB could possess different mechanical properties.

关 键 词：生物可降解材料 P3HB4HB 热性能 结晶性能 力学性能 

分 类 号：O631[理学—高分子化学]