赤藓红共振瑞利散射光谱法测定盐酸多塞平  

Resonance Rayleigh Scattering Spectrometric Determination of Doxepin Hydrochloride by Its Reaction with Erythrosine

作　　者：朱乾华[1] 万帮江[1] 张敏[2] 杨季冬[2,3] 

机构地区：[1]长江师范学院化学化工学院,重庆408100 [2]西南大学化学化工学院,重庆400715 [3]重庆三峡学院化学与环境工程学院,重庆404000

出　　处：《理化检验（化学分册）》2012年第10期1158-1160,1163,共4页Physical Testing and Chemical Analysis(Part B:Chemical Analysis)

基　　金：重庆市教委项目(KJ121306)资助;重庆市涪陵区科技计划项目(FLKJ;2010ABA1012)

摘　　要：在pH 4.5的B-R缓冲溶液中,一定量的盐酸多塞平与1.0×10-4 mol.L-1赤藓红溶液1.0mL在总体积10mL中反应生成离子缔合物,产生共振瑞利散射光谱,在其最大共振光散射峰波长284nm处测定共振瑞利散射的强度IRRS。盐酸多塞平的质量浓度在0.10～4.2mg.L-1范围内与样品及空白溶液值之差ΔIRRS呈线性关系,方法的检出限(3s/k)为9.01μg.L-1。方法用于药物中盐酸多塞平的测定,测得结果与药典法测得结果相符,回收率在98.9%～102%之间。In a B-R buffer medium of pH 4. 5, an appropriate amount of doxepin hydrochloride sample solution was reacted with 1.0 mL of 1.0×10^-4mol·L^-1 erythrosine solution in a total volume of 10 mL, to form an ion association complex, of which the intensity of resonance Rayleigh scattering （ IRRS ） was measured at the wavelength of 284 nm. Values of ＆IRRs （difference between values of IRRS of sample and blank） was found to keep linear relationship with values of mass concentration of doxepin hydrochloride in the range of 0.10-4. 2 mg·L^-1, with limit of detection （3s/k） of 9.01 μg·L^-1 The proposed method was applied to the determination of doxepin hydrochloride in sample of medicine, results obtained by this method were found to check quite well with the results found by the method of pharmacopeia. Values of recovery found were in the range of 98. 9%-102%.

关 键 词：共振瑞利散射光谱法 盐酸多塞平 赤藓红 

分 类 号：O657.32[理学—分析化学]