短期胰岛素泵治疗对2型糖尿病患者血内脏脂肪素的影响  

Effects of short continuous subcutaneous insulin infusion on visfatin in type 2 diabetes patients

作　　者：韩瑛[1] 王永丰[1] 杜玲[1] 徐黎鸣[1] 

机构地区：[1]十堰市湖北医药学院附属太和医院细胞治疗中心,湖北十堰442000

出　　处：《中国热带医学》2012年第10期1254-1255,共2页China Tropical Medicine

摘　　要：目的比较短期胰岛素泵治疗对不同病程2型糖尿病患者血内脏脂肪素(visfatin,VF)的影响。方法选择2型糖尿病患者100例,根据病程分为观察组40例(初诊病程<1年)和对照组60例(病程1～10年)。两组均使用胰岛素泵持续皮下输注超短效胰岛素(诺和锐)2周。比较两组空腹血糖(FBG)、餐后2h血糖(2hFBG)、糖化血清白蛋白(GA)、空腹内脏脂肪素(VF)、空腹C肽(C-P)等变化。结果两组FPG、2hFPG、GA、C-P、空腹内脏脂肪素差异均有统计学意义(t=3.573,P<0.05);两组治疗前后变化量比较具有统计学意义(t=2.784,P<0.05),VF与FBG、2hFPG及GA成正相关。结论早期胰岛素泵强化治疗能够很好控制血糖水平,对改善β细胞功能及胰岛素抵抗有着重要的作用,而这种作用在1年以上病程的患者中表现相对不明显。Objective To observe effect of insulin infusion on type 2 diabetes patients. Methods A hundred type 2 diabetes patients were divided into experimental group （ 40 newly diagnosed patients with diseae course of a year） and control group （ 60 diabetes with a course of 1-10 years）. The patients in both groups were with insulin pump for 2 weeks. The levels of FPG, 2hFPG,GA,VF,C-P were analyzed. Results The levels of FPG, 2hFPG, CA, C-P and VF in two groups were significantly difference （P〈0.05）. The level of VF was positively correlated with that of FBG, 2hFPG, GA. Conclusion Early treatment of type 2 diabetes patients with nsulin pump if effective in controlling blood glucose, improving I3-cell function and insulin resistance.

关 键 词：2型糖尿病 胰岛素泵 内脏脂肪素 

分 类 号：R587.1[医药卫生—内分泌]