Accelerated Curing Speed of Ethyl a-Cyanoacrylate by Polymer with Catecholamine Groups  

作　　者：张峰 刘四委 张艺 许家瑞 危岩 

机构地区：[1]PCFM Lab,School of Chemistry and Chemical Engineering,Sun Yat-sen University,Guangzhou,Guangdong 510275,China [2]Department of Chemistry,Tsinghua University,Beijing 100084,China

出　　处：《Chinese Journal of Chemistry》2012年第10期2275-2280,共6页中国化学（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China （Nos. 50903096, 21134004）, the Department of Science Technology of Guangdong Province （No. 2008B090500196）, and the Fundamental Research Funds for the Central Universi- ties.

摘　　要：Four kinds of poly（ethylene glycol） （PEG） derivatives with the similar backbone and different side groups have been synthesized successfully. When both catecholamine and double bond are tethered to polymer backbone, i.e., the PEG backbone, simultaneously, the polymer can accelerate the curing speed of ethyl a-cyanoacrylate （commer- cially available as 502） greatly under the same conditions （the curing time of such system is no more than 5 s）. Probably this is due to the autoxidation of catecholamines. Through the redox-cycling, catecholamines can produce, collect free radicals, and thus initiate the free radical polymerization. Due to the fast-curing of such material when mixed with a-cyanoacrylate, we could design and develop a new bicomponent super bioglue used in the dentistry or other bioenvironment requiring super fast settlement for further surgical operations.Four kinds of poly（ethylene glycol） （PEG） derivatives with the similar backbone and different side groups have been synthesized successfully. When both catecholamine and double bond are tethered to polymer backbone, i.e., the PEG backbone, simultaneously, the polymer can accelerate the curing speed of ethyl a-cyanoacrylate （commer- cially available as 502） greatly under the same conditions （the curing time of such system is no more than 5 s）. Probably this is due to the autoxidation of catecholamines. Through the redox-cycling, catecholamines can produce, collect free radicals, and thus initiate the free radical polymerization. Due to the fast-curing of such material when mixed with a-cyanoacrylate, we could design and develop a new bicomponent super bioglue used in the dentistry or other bioenvironment requiring super fast settlement for further surgical operations.

关 键 词：CATECHOLAMINES dopamines radical reactions BIOADHESION 

分 类 号：TQ323.5[化学工程—合成树脂塑料工业] Q42[生物学—神经生物学]