Thiol-yne Click Adamantane Monolithic Stationary Phase for Capillary Electrochromatography  

作　　者：Dao,Thi Thu Hien Guerrouache,Mohamed Carbonnier,Benjamin 

机构地区：[1]Institut de Chimie et des Materiaux Paris Est,UMRCNRS 7182&Universite Paris-Est Creteil,2-8 rue Henri Dunant,94320 Thiais,France

出　　处：《Chinese Journal of Chemistry》2012年第10期2281-2284,共4页中国化学（英文版）

摘　　要：A porous crosslinked organic polymer based on N-acryloxysuccinimide （NAS） and ethylene dimethacrylate （EDMA） was prepared inside 75 μm i.d. fused silica capillary as functionalizable monolithic stationary phase for electrochromatographic applications. Succinimide groups on the monolith surface provide reactive sites able to re- act readily through standard electrophile-nucleophile chemistry. Propargylamine was used to prepare alkyne func- tionalized poly（NAS-co-EDMA）. Onto this thiol-reactive polymer surface was grafted adamantane units via a photochemically-driven addition reaction. Chemical characterization was performed in situ after each synthetic step by means of Raman spectroscopy and grafting kinetics was investigated to ensure quantitative grafting of 1-adamantanethiol. The as-designed monolithic stationary phase exhibited typical reversed-phase separation mechanism as evidenced by the linear increase of the logarithm of retention factor of neutral aromatic solutes with the increase of the aqueous buffer content in the mobile phase.A porous crosslinked organic polymer based on N-acryloxysuccinimide （NAS） and ethylene dimethacrylate （EDMA） was prepared inside 75 μm i.d. fused silica capillary as functionalizable monolithic stationary phase for electrochromatographic applications. Succinimide groups on the monolith surface provide reactive sites able to re- act readily through standard electrophile-nucleophile chemistry. Propargylamine was used to prepare alkyne func- tionalized poly（NAS-co-EDMA）. Onto this thiol-reactive polymer surface was grafted adamantane units via a photochemically-driven addition reaction. Chemical characterization was performed in situ after each synthetic step by means of Raman spectroscopy and grafting kinetics was investigated to ensure quantitative grafting of 1-adamantanethiol. The as-designed monolithic stationary phase exhibited typical reversed-phase separation mechanism as evidenced by the linear increase of the logarithm of retention factor of neutral aromatic solutes with the increase of the aqueous buffer content in the mobile phase.

关 键 词：ADAMANTANE ELECTROCHROMATOGRAPHY porous monolith surface chemistry thiol-yne click 

分 类 号：O657.71[理学—分析化学] O657.8[理学—化学]