An Efficient α-Alkylation of Aromatic Ketones with Primary Alcohols Catalyzed by [Cp＊IrCI2]2 without Solvent  

作　　者：李剑 张卫星 王锋 江敏 董肖椿 赵伟利 

机构地区：[1]School of Pharmacy,Fudan University,Shanghai 201203,China [2]Key Laboratory for Special Functional Materials of the Ministry of Education,1-Ienan University,Kaifeng,Henan 475004,China [3]Roche Pharma Research and Early Development China,Shanghai 201203,China

出　　处：《Chinese Journal of Chemistry》2012年第10期2363-2366,共4页中国化学（英文版）

摘　　要：Aromatic ketones are directly alkylated at a position with primary alcohols at 110 ℃ in the presence of catalytic amount of KOH and [Cp＊lrC12]2 （Cp＊=pentamethylcyclopentadienyl） catalyst. The reaction is carried out in the absence of any solvent or additive, which generates only water as the byproduct in theory. It is very efficient and generally completed in 10 min in good isolated yields. The reaction is believed to undergo successive hydrogen transfer and cross aldol condensation processes.Aromatic ketones are directly alkylated at a position with primary alcohols at 110 ℃ in the presence of catalytic amount of KOH and [Cp＊lrC12]2 （Cp＊=pentamethylcyclopentadienyl） catalyst. The reaction is carried out in the absence of any solvent or additive, which generates only water as the byproduct in theory. It is very efficient and generally completed in 10 min in good isolated yields. The reaction is believed to undergo successive hydrogen transfer and cross aldol condensation processes.

关 键 词：carbon-carbon α-bond formation iridium catalyzed hydrogen transfer a-alkylation of ketones aldolcondensation SOLVENT-FREE 

分 类 号：O643.36[理学—物理化学] TQ633[理学—化学]