杂多化合物九钨三钛硅酸盐致畸毒性研究  

Teratogenicity of Polyoxometalate α-K_8H_2〔SiW_9Ti_3O_(40) 〕·15H_2O(α-Ti_3)

作　　者：刘娅[1] 章培标 王宝贵 赵林伊 刘景福[3] 孟路[3] 

机构地区：[1]白求恩医大预防医学院营养与食品卫生教研室,吉林长春130021 [2]长春市卫生防疫站 [3]东北师范大学化学系

出　　处：《白求恩医科大学学报》2000年第2期126-130,共5页Journal of Norman Bethune University of Medical Science

摘　　要：目的 :观察九钨三钛硅酸盐 ( α- K8H2 〔Si W9Ti3 O4 0 〕· 1 5H2 O,简称 α- Ti3 )孕期给药对大鼠胎仔的毒性影响。方法 :大鼠孕期以 57.0 9,1 71 .2 8和 51 3.83mg/ kg剂量经口给予α- Ti3 ,并以Vit A为阳性对照及蒸馏水为阴性对照 ,产前剖腹检测胎鼠生长发育指标、外观内脏骨骼形态等。结果 :三个剂量组均未见胎鼠外观、内脏及骨骼畸形。低剂量组与高剂量组的活胎率升高 ,吸收胎数下降 ,与阴性对照组比较有显著性差异 (均为 P<0 .0 5)。低、中、高剂量组的胎鼠体重和身长高于阴性对照组 (分别为 P<0 .0 5,P<0 .0 1 ,P<0 .0 1 ) ,且增长程度与剂量呈正相关 ( r=0 .840 8,0 .72 2 8,P<0 .0 0 5,0 .0 5)。低、中、高三个剂量组的上枕骨骨化程度及胸骨块数高于阴性对照组和阳性对照组 ( P<0 .0 5,0 .0 1 ,0 .0 1 ,0 .0 5和 P<0 .0 5,0 .0 1 ,0 .0 1 )。各剂量组的母鼠肝脏重量及肝体比值不同程度下降。其中 ,中、高剂量组及阳性对照组的肝重及肝体比值与阴性对照组比较差异显著 (肝重比较分别为 P<0 .0 5,P<0 .0 5和 P<0 .0 1 ,肝体比值比较均为 P<0 .0 5)。结论 :α- Ti3 致畸试验未见胎鼠畸形 ,但可提高胎鼠生长发育指标和骨骼骨化程度。? Objective:The test of teratogenicity of polyoxometalate α K 8H 2〔SiW 9Ti 3O 40 〕·15H 2O (α Ti 3) was used to detect the growing index and abnormality of fetus in Wistar rats.Methods:From 7 to 16 days after certification,female Wistar rats were administrated orally α Ti 3 with doses of 57.09,171.28, 513.83 mg/kg ;meanwhile,distilled water and Vit A were used for the negative and positive control groups respectively .Results:No abnormalities in appearance,viscus and bones of fetus were observed in all three dose groups.Compared with the negative control group,the rates of live fetus increased but the number of absorbed fetus decreased in the group of 57.09,513.83 mg/kg ( P <0 05).There were significant increases of body weight,body height and tail length of fetus in the groups of 57.09,171.28,513.83 mg/kg;compared with the negative control group ( P <0 05,0.01,0.01 and P <0 05,0.01,0.01),which was markedly associated with dose levels ( r =0.8408,0.7228 and P <0 005,0.05 respectively).Analysis of ossification grade of upper occipital and the number of fetal sternum showed that ossification in fetus of all three dose groups was higher than that of the negative control group ( P <0 05,0.01,0.01).Marked decreases of hepatic weight and hepatic body ratios of pregnant rats were observed in the groups of 57.09,171.28 and 513.83 mg/kg,compared with the negative control group ( P <0 05,0.05,0.01 and P <0 05,0.05,respectively).Conclusion:There were no abnormalities but increases of growing indexes and higher ossification of fetus in the teratogenicity test of α Ti 3. 〔

关 键 词：杂多化合物 九钨三钛硅酸盐 大鼠 致畸毒性 

分 类 号：R714.530.2[医药卫生—妇产科学] R979.1[医药卫生—临床医学]